Detailed information of TA system TA147341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 53461..53966
• Replicon: chromosome
• Accession: NZ_CP047698
• Organism: Pseudomonas knackmussii strain N1-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GVI47_RS00270
• Protein ID: WP_160285418.1
• Coordinates: 53461..53742 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GVI47_RS00275
• Protein ID: WP_160285419.1
• Coordinates: 53739..53966 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVI47_RS00250	50712..51167	-	456	WP_043248040.1	GNAT family N-acetyltransferase	-
GVI47_RS00255	51212..52144	-	933	WP_160285415.1	LysR family transcriptional regulator	-
GVI47_RS00260	52239..52520	+	282	WP_160285416.1	DUF2218 domain-containing protein	-
GVI47_RS00265	52551..53183	-	633	WP_160285417.1	RcnB family protein	-
GVI47_RS00270	53461..53742	-	282	WP_160285418.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GVI47_RS00275	53739..53966	-	228	WP_160285419.1	ribbon-helix-helix protein, CopG family	Antitoxin
GVI47_RS00280	54189..54944	+	756	WP_160285420.1	phytanoyl-CoA dioxygenase family protein	-
GVI47_RS00285	54956..55357	+	402	WP_160285421.1	GFA family protein	-
GVI47_RS00290	55365..57326	-	1962	WP_043248051.1	DUF4105 domain-containing protein	-
GVI47_RS00295	57323..57658	-	336	WP_160285422.1	DUF2388 domain-containing protein	-
GVI47_RS00300	57698..57994	-	297	WP_043248055.1	DUF2388 domain-containing protein	-
GVI47_RS00305	58111..58428	-	318	WP_043248056.1	DUF2388 domain-containing protein	-
GVI47_RS00310	58517..58714	-	198	WP_160288856.1	DUF1127 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10289.76 Da
• Isoelectric Point: 5.6557

>T147341 WP_160285418.1 NZ_CP047698:c53742-53461 [Pseudomonas knackmussii]
MSLQWTHKAAADLDGLYDHYVVLVGPEKALRAIQDMVGQVKALADLSLSSVGQPSEVPGVRELLLERWPYQAAYRVKGRD
VQILRIDSVENSG

Nucleotide

• Length: 282 bp

>T147341 NZ_CP062908:c4276012-4275839 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8431.46 Da
• Isoelectric Point: 6.3202

>AT147341 WP_160285419.1 NZ_CP047698:c53966-53739 [Pseudomonas knackmussii]
MTTVISFRADDALAAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGLADANAGHLLDHVEIERKWGLA

Nucleotide

• Length: 228 bp

>AT147341 NZ_CP062908:c4276336-4276040 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG