Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3295952..3297146 Replicon chromosome
Accession NZ_CP047697
Organism Pseudomonas aeruginosa strain RD1-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GVI48_RS15410 Protein ID WP_003114949.1
Coordinates 3295952..3296530 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GVI48_RS15415 Protein ID WP_034054867.1
Coordinates 3296619..3297146 (-) Length 176 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI48_RS15395 3291229..3292506 + 1278 WP_003102743.1 TolC family protein -
GVI48_RS15400 3292496..3294667 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
GVI48_RS15405 3294657..3295844 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
GVI48_RS15410 3295952..3296530 - 579 WP_003114949.1 HD domain-containing protein Toxin
GVI48_RS15415 3296619..3297146 - 528 WP_034054867.1 helix-turn-helix domain-containing protein Antitoxin
GVI48_RS15420 3297330..3299525 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
GVI48_RS15425 3299530..3299991 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
GVI48_RS15430 3300322..3300645 + 324 WP_003102734.1 multidrug efflux SMR transporter -
GVI48_RS15435 3300658..3301056 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
GVI48_RS15440 3301053..3301604 - 552 WP_003450159.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-53)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T147339 WP_003114949.1 NZ_CP047697:c3296530-3295952 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T147339 NZ_CP062908:c4018627-4018340 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTGGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCG
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 176 a.a.        Molecular weight: 19542.62 Da        Isoelectric Point: 8.5375

>AT147339 WP_034054867.1 NZ_CP047697:c3297146-3296619 [Pseudomonas aeruginosa]
MGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEANPQPVHLICD
LTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPIRRSRCRWTR
MTLSDGRAVRLVETL

Download         Length: 528 bp

>AT147339 NZ_CP062908:c4018353-4018051 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAATTGAAGGCGCTGGCGAA
TAAATCCGACGAAGAGATTGATTACAGCGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References