Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143518..144023 Replicon chromosome
Accession NZ_CP047697
Organism Pseudomonas aeruginosa strain RD1-3

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag GVI48_RS00655 Protein ID WP_003083773.1
Coordinates 143518..143799 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag GVI48_RS00660 Protein ID WP_003083775.1
Coordinates 143796..144023 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI48_RS00630 138769..140118 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
GVI48_RS00635 140167..140853 + 687 WP_003083762.1 FadR family transcriptional regulator -
GVI48_RS00640 140954..141688 + 735 WP_003117208.1 GntR family transcriptional regulator -
GVI48_RS00645 141892..142278 + 387 WP_003083767.1 aegerolysin family protein -
GVI48_RS00650 142310..143218 - 909 WP_003083769.1 LysR family transcriptional regulator -
GVI48_RS00655 143518..143799 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
GVI48_RS00660 143796..144023 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
GVI48_RS00665 144198..144818 - 621 WP_003101226.1 hypothetical protein -
GVI48_RS00670 144919..145419 + 501 WP_003162763.1 LEA type 2 family protein -
GVI48_RS00675 145492..145833 + 342 WP_003101229.1 alkylphosphonate utilization protein -
GVI48_RS00680 145915..147342 - 1428 WP_003083784.1 GABA permease -
GVI48_RS00685 147511..149004 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T147336 WP_003083773.1 NZ_CP047697:c143799-143518 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T147336 NZ_CP062908:2643594-2643701 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT147336 WP_003083775.1 NZ_CP047697:c144023-143796 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT147336 NZ_CP062908:c2643547-2643481 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References