Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 126803..127359 Replicon chromosome
Accession NZ_CP047696
Organism Marinomonas mediterranea MMB-1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GV053_RS00565 Protein ID WP_263053313.1
Coordinates 126803..127072 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F2JVG1
Locus tag GV053_RS00570 Protein ID WP_013659326.1
Coordinates 127075..127359 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV053_RS00545 (GV053_00535) 123724..124323 - 600 WP_013659322.1 cysteine hydrolase family protein -
GV053_RS00550 (GV053_00540) 124469..125329 - 861 WP_013659323.1 LysR family transcriptional regulator -
GV053_RS00555 (GV053_00545) 125352..126152 - 801 WP_013659324.1 helix-turn-helix domain-containing protein -
GV053_RS00560 (GV053_00550) 126256..126690 + 435 WP_013659325.1 hypothetical protein -
GV053_RS00565 (GV053_00555) 126803..127072 + 270 WP_263053313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GV053_RS00570 (GV053_00560) 127075..127359 + 285 WP_013659326.1 putative addiction module antidote protein Antitoxin
GV053_RS00575 (GV053_00565) 127768..128253 + 486 WP_263053295.1 LysE family translocator -
GV053_RS00580 (GV053_00570) 128569..129852 + 1284 WP_013659327.1 urea ABC transporter substrate-binding protein -
GV053_RS00585 (GV053_00575) 130400..131974 + 1575 WP_049787804.1 urea ABC transporter permease subunit UrtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-84)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10241.85 Da        Isoelectric Point: 10.4613

>T147332 WP_263053313.1 NZ_CP047696:126803-127072 [Marinomonas mediterranea MMB-1]
MTGLKDKKTKIRLSRRLEKVSRGLLGDVRAVGEDVFEMREHFGPGWRMYYAQVGDEIIVMLGGGDKSTQSNDIYTAPKIA
KQLKEQRWR

Download         Length: 270 bp

>T147332 NZ_CP062908:1983608-1983711 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10357.80 Da        Isoelectric Point: 5.6210

>AT147332 WP_013659326.1 NZ_CP047696:127075-127359 [Marinomonas mediterranea MMB-1]
MQLKNFDMAEQLRDDEDIAEYLSQVLEEGDTDELIHALGHVAKAKGMTQVAKDSGLGRESLYKALRVGSKPQFSTVVKVL
KALNFDLQAVAHKG

Download         Length: 285 bp

>AT147332 NZ_CP062908:c1983749-1983478 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB F2JVG1

References