Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4501221..4502928 Replicon chromosome
Accession NZ_CP047695
Organism Marinomonas mediterranea strain MMB-2 (IVIA-Po-186)

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag GV054_RS20610 Protein ID WP_272641883.1
Coordinates 4501221..4502144 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag GV054_RS20615 Protein ID WP_272643590.1
Coordinates 4502137..4502928 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV054_RS20590 (GV054_20500) 4497236..4498318 - 1083 WP_272643587.1 DNA cytosine methyltransferase -
GV054_RS20595 (GV054_20505) 4498311..4498643 - 333 WP_272643588.1 helix-turn-helix domain-containing protein -
GV054_RS20600 (GV054_20510) 4498650..4498949 - 300 WP_272643589.1 hypothetical protein -
GV054_RS20605 (GV054_20520) 4500454..4501194 + 741 WP_272641882.1 class I SAM-dependent methyltransferase -
GV054_RS20610 (GV054_20525) 4501221..4502144 - 924 WP_272641883.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GV054_RS20615 (GV054_20530) 4502137..4502928 - 792 WP_272643590.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GV054_RS20620 (GV054_20535) 4503141..4504913 - 1773 WP_272643591.1 diguanylate cyclase -
GV054_RS20625 (GV054_20540) 4505092..4505910 - 819 WP_272643592.1 RNA methyltransferase -
GV054_RS20630 (GV054_20545) 4506003..4506623 + 621 WP_272643593.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -
GV054_RS20635 (GV054_20550) 4506728..4507795 + 1068 WP_013663176.1 23S rRNA pseudouridine(2604) synthase RluF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-279)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-96)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35050.45 Da        Isoelectric Point: 5.0239

>T147331 WP_272641883.1 NZ_CP047695:c4502144-4501221 [Marinomonas mediterranea]
MDRESPYYKQLSLLIRMLPIVATESVFALKGGTAINLFVRNFPRLSVDIDLAYLPLEPRIEALENVKAALKRIVDLINAQ
PDTRAVLQDQKVDELRIVVTSLNATIKIEVSPVARGTLHKPNNLPVQELVEEEYGYAEISVVSLPDLYGGKLCAAMDRQH
PRDLFDVRTLLLEEGISRDIFIGFITYALSHPRPINEVMAPNWQPLDETFKAEFDGMTFEPVNLEDLLSVRSKMVNELKK
HFTKEDRAFLLSFKQGNPDWTLFDYPDAANLPAIRWKLQNLDKLAKNQAKHKEQLAKLEAVLDEWLE

Download         Length: 924 bp

>T147331 NZ_CP062908:c1812495-1812121 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 29943.39 Da        Isoelectric Point: 9.6986

>AT147331 WP_272643590.1 NZ_CP047695:c4502928-4502137 [Marinomonas mediterranea]
MSSKINWLVTHTSPGALVLQQWLTENGISYSLAQKYTKSGWLMKLSSGVYYRPSANGDSKPDWTEALQATDIQLRLPVHL
AGLGSLTHQGLSHYLSVGKEQVWVGVKSKQSLPKWFREFPDQNWFYCGNHKLEIVPEKDLKVIMVKGKALKASCPELAAY
EVVDAIGKLISFEHAAELFQGLVNLSPRKVQSLLERSRSVQTNRVFLFLCHFYDHQWVQRLDETKIGLGSGKRQVVEKGR
LDERYQITVPEKFLAKQEEQRNG

Download         Length: 792 bp

>AT147331 NZ_CP062908:c1812953-1812585 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References