Detailed information of TA system TA147328

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1802881..1803443
• Replicon: chromosome
• Accession: NZ_CP047695
• Organism: Marinomonas mediterranea strain MMB-2 (IVIA-Po-186)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F2JZS5
• Locus tag: GV054_RS08310
• Protein ID: WP_013660834.1
• Coordinates: 1802881..1803162 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F2JZS6
• Locus tag: GV054_RS08315
• Protein ID: WP_013660835.1
• Coordinates: 1803159..1803443 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV054_RS08285 (GV054_08245)	1799920..1800480	+	561	WP_272644178.1	hypothetical protein	-
GV054_RS08290 (GV054_08250)	1800595..1801230	+	636	WP_272644179.1	HD domain-containing protein	-
GV054_RS08295 (GV054_08255)	1801271..1801561	-	291	WP_272644180.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GV054_RS08300 (GV054_08260)	1801554..1801775	-	222	WP_013660827.1	hypothetical protein	-
GV054_RS08305	1802064..1802429	+	366	WP_272644181.1	hypothetical protein	-
GV054_RS08310 (GV054_08270)	1802881..1803162	-	282	WP_013660834.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GV054_RS08315 (GV054_08275)	1803159..1803443	-	285	WP_013660835.1	DNA-damage-inducible protein J	Antitoxin
GV054_RS08320 (GV054_08280)	1803674..1804201	+	528	WP_049787762.1	transposase	-
GV054_RS08325 (GV054_08285)	1804520..1806136	+	1617	WP_013660836.1	TIGR04141 family sporadically distributed protein	-
GV054_RS08330 (GV054_08290)	1806184..1806825	+	642	WP_013660837.1	hypothetical protein	-
GV054_RS08335 (GV054_08295)	1807270..1807938	+	669	WP_013660838.1	hypothetical protein	-
GV054_RS08340 (GV054_08300)	1807978..1808385	+	408	WP_041647832.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10808.69 Da
• Isoelectric Point: 5.7134

>T147328 WP_013660834.1 NZ_CP047695:c1803162-1802881 [Marinomonas mediterranea]
MIVWEKSSLDDREAIFEFLYDFNPLAAEKTDAIIEKKVKNLNQQPLMGVEREGIPGRLLIIPEVSMIVSYFIKDEIIHIL
RVLHQKQKFPVGN

Nucleotide

• Length: 282 bp

>T147328 NZ_CP062908:1014283-1014618 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10979.35 Da
• Isoelectric Point: 6.4762

>AT147328 WP_013660835.1 NZ_CP047695:c1803443-1803159 [Marinomonas mediterranea]
MDTRIQFRVDEETKRLAQITAESQGRTLSDACRELTEELAEQQRKIITHDQWLTEEVNAAFNKLESGQSKFVSHEEANLD
MEARKMKIRNKAKK

Nucleotide

• Length: 285 bp

>AT147328 NZ_CP062908:1014035-1014283 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: F2JZS5

Antitoxin

• AlphaFold DB: F2JZS6