Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4473746..4474415 Replicon chromosome
Accession NZ_CP047691
Organism Serratia marcescens strain C110

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag GV213_RS21365 Protein ID WP_047570653.1
Coordinates 4473746..4474168 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag GV213_RS21370 Protein ID WP_004931679.1
Coordinates 4474149..4474415 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV213_RS21345 4469635..4470153 + 519 WP_004931683.1 flavodoxin FldB -
GV213_RS21350 4470191..4471555 - 1365 WP_047570659.1 cell envelope integrity protein CreD -
GV213_RS21355 4471636..4473054 - 1419 WP_047570657.1 two-component system sensor histidine kinase CreC -
GV213_RS21360 4473051..4473746 - 696 WP_047570655.1 two-component system response regulator CreB -
GV213_RS21365 4473746..4474168 - 423 WP_047570653.1 protein YgfX Toxin
GV213_RS21370 4474149..4474415 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
GV213_RS21375 4474736..4475728 + 993 WP_047570651.1 tRNA-modifying protein YgfZ -
GV213_RS21380 4475767..4476264 - 498 WP_033649451.1 DUF2165 domain-containing protein -
GV213_RS21385 4476415..4477089 - 675 WP_033639467.1 hemolysin III family protein -
GV213_RS21390 4477273..4477881 + 609 WP_047570649.1 HD domain-containing protein -
GV213_RS21395 4477922..4478848 - 927 WP_038871218.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4467690..4526130 58440


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16457.56 Da        Isoelectric Point: 10.8114

>T147318 WP_047570653.1 NZ_CP047691:c4474168-4473746 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLSHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Download         Length: 423 bp

>T147318 NZ_CP062903:15459-15740 [Escherichia coli O152:H23]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT147318 WP_004931679.1 NZ_CP047691:c4474415-4474149 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT147318 NZ_CP062903:15193-15462 [Escherichia coli O152:H23]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References