Detailed information of TA system TA147316

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4232339..4232976
• Replicon: chromosome
• Accession: NZ_CP047691
• Organism: Serratia marcescens strain C110

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GV213_RS20220
• Protein ID: WP_049191603.1
• Coordinates: 4232701..4232976 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GV213_RS20215
• Protein ID: WP_094888665.1
• Coordinates: 4232339..4232704 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV213_RS20200	4228967..4230058	+	1092	WP_094887884.1	phage portal protein	-
GV213_RS20205	4230509..4231087	+	579	WP_094888669.1	sce7726 family protein	-
GV213_RS20210	4231047..4232147	-	1101	WP_094888667.1	beta family protein	-
GV213_RS20215	4232339..4232704	-	366	WP_094888665.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GV213_RS20220	4232701..4232976	-	276	WP_049191603.1	type II toxin-antitoxin system HicA family toxin	Toxin
GV213_RS20225	4233046..4233741	-	696	WP_060417685.1	DNA adenine methylase	-
GV213_RS20230	4233890..4236373	-	2484	WP_094887886.1	replication endonuclease	-
GV213_RS26555	4236373..4236909	-	537	WP_201751705.1	hypothetical protein	-
GV213_RS20240	4236906..4237175	-	270	WP_094887887.1	DUF3850 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4202499..4243425	40926

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (62-114)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10099.70 Da
• Isoelectric Point: 10.6115

>T147316 WP_049191603.1 NZ_CP047691:c4232976-4232701 [Serratia marcescens]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T147316 NZ_CP062901:c4320345-4320172 [Escherichia coli O152:H23]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13315.04 Da
• Isoelectric Point: 4.5702

>AT147316 WP_094888665.1 NZ_CP047691:c4232704-4232339 [Serratia marcescens]
MTKTAAVTPNTMEIAGQPAIISYVPEIGTFRGKFLGLSGYCDFVSDSIQGLKAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVDTLNERMKHA

Nucleotide

• Length: 366 bp

>AT147316 NZ_CP062901:c4320669-4320373 [Escherichia coli O152:H23]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG