Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4058772..4059428 Replicon chromosome
Accession NZ_CP047691
Organism Serratia marcescens strain C110

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GV213_RS19365 Protein ID WP_033648839.1
Coordinates 4058772..4059161 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag GV213_RS19370 Protein ID WP_004941563.1
Coordinates 4059165..4059428 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV213_RS19350 4055239..4056669 + 1431 WP_160866766.1 MFS transporter -
GV213_RS19355 4056666..4058048 + 1383 WP_094860007.1 two-component system sensor histidine kinase BaeS -
GV213_RS19360 4058048..4058764 + 717 WP_033635542.1 two-component system response regulator BaeR -
GV213_RS19365 4058772..4059161 - 390 WP_033648839.1 type II toxin-antitoxin system VapC family toxin Toxin
GV213_RS19370 4059165..4059428 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GV213_RS19375 4059768..4060106 + 339 WP_094860008.1 YegP family protein -
GV213_RS19380 4060287..4061639 + 1353 WP_033635545.1 tRNA 5-hydroxyuridine modification protein YegQ -
GV213_RS19385 4062106..4063011 + 906 WP_033635546.1 lipid kinase YegS -
GV213_RS19390 4063178..4064392 + 1215 WP_094860009.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14277.50 Da        Isoelectric Point: 7.8786

>T147315 WP_033648839.1 NZ_CP047691:c4059161-4058772 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSVVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T147315 NZ_CP062901:c4224617-4224267 [Escherichia coli O152:H23]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT147315 WP_004941563.1 NZ_CP047691:c4059428-4059165 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT147315 NZ_CP062901:c4224862-4224611 [Escherichia coli O152:H23]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References