Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3982695..3983332 Replicon chromosome
Accession NZ_CP047691
Organism Serratia marcescens strain C110

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GV213_RS19025 Protein ID WP_049191603.1
Coordinates 3983057..3983332 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GV213_RS19020 Protein ID WP_094888665.1
Coordinates 3982695..3983060 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV213_RS19005 3979323..3980414 + 1092 WP_094887884.1 phage portal protein -
GV213_RS19010 3980865..3981443 + 579 WP_094888669.1 sce7726 family protein -
GV213_RS19015 3981403..3982503 - 1101 WP_094888667.1 beta family protein -
GV213_RS19020 3982695..3983060 - 366 WP_094888665.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GV213_RS19025 3983057..3983332 - 276 WP_049191603.1 type II toxin-antitoxin system HicA family toxin Toxin
GV213_RS19030 3983402..3984097 - 696 WP_060417685.1 DNA adenine methylase -
GV213_RS19035 3984246..3986729 - 2484 WP_094887886.1 replication endonuclease -
GV213_RS26545 3986729..3987265 - 537 WP_201751705.1 hypothetical protein -
GV213_RS19045 3987262..3987531 - 270 WP_094887887.1 DUF3850 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3956743..3992532 35789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10099.70 Da        Isoelectric Point: 10.6115

>T147314 WP_049191603.1 NZ_CP047691:c3983332-3983057 [Serratia marcescens]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Download         Length: 276 bp

>T147314 NZ_CP062901:3416525-3416743 [Escherichia coli O152:H23]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13315.04 Da        Isoelectric Point: 4.5702

>AT147314 WP_094888665.1 NZ_CP047691:c3983060-3982695 [Serratia marcescens]
MTKTAAVTPNTMEIAGQPAIISYVPEIGTFRGKFLGLSGYCDFVSDSIQGLKAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVDTLNERMKHA

Download         Length: 366 bp

>AT147314 NZ_CP062901:3416125-3416499 [Escherichia coli O152:H23]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References