Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1176541..1177162 Replicon chromosome
Accession NZ_CP047691
Organism Serratia marcescens strain C110

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag GV213_RS05560 Protein ID WP_004940313.1
Coordinates 1176541..1176744 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag GV213_RS05565 Protein ID WP_004940312.1
Coordinates 1176794..1177162 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV213_RS05535 1172327..1172773 + 447 WP_047568994.1 type II secretion system protein M -
GV213_RS05540 1172809..1173624 + 816 WP_052133456.1 A24 family peptidase -
GV213_RS05545 1173621..1173983 - 363 WP_033653248.1 type II secretion system pilot lipoprotein GspS -
GV213_RS05550 1174237..1175673 + 1437 WP_047568993.1 N-acetylglucosamine-binding protein GbpA -
GV213_RS05555 1175726..1176244 + 519 WP_047568991.1 cytochrome b/b6 domain-containing protein -
GV213_RS05560 1176541..1176744 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
GV213_RS05565 1176794..1177162 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
GV213_RS05570 1177321..1177674 - 354 WP_033653245.1 hypothetical protein -
GV213_RS05575 1178082..1178795 + 714 WP_047568987.1 ABC transporter ATP-binding protein -
GV213_RS05580 1178792..1179649 + 858 WP_033637343.1 metal ABC transporter permease -
GV213_RS05585 1179675..1180553 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
GV213_RS05590 1180660..1180800 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
GV213_RS05595 1180813..1181067 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T147303 WP_004940313.1 NZ_CP047691:c1176744-1176541 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T147303 NZ_CP062901:1029360-1029695 [Escherichia coli O152:H23]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT147303 WP_004940312.1 NZ_CP047691:c1177162-1176794 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT147303 NZ_CP062901:1029112-1029360 [Escherichia coli O152:H23]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References