Detailed information of TA system TA147296

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4473911..4474580
• Replicon: chromosome
• Accession: NZ_CP047688
• Organism: Serratia marcescens strain 1140-

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: GV224_RS21370
• Protein ID: WP_047570653.1
• Coordinates: 4473911..4474333 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: GV224_RS21375
• Protein ID: WP_004931679.1
• Coordinates: 4474314..4474580 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV224_RS21350	4469800..4470318	+	519	WP_004931683.1	flavodoxin FldB	-
GV224_RS21355	4470356..4471720	-	1365	WP_047570659.1	cell envelope integrity protein CreD	-
GV224_RS21360	4471801..4473219	-	1419	WP_047570657.1	two-component system sensor histidine kinase CreC	-
GV224_RS21365	4473216..4473911	-	696	WP_047570655.1	two-component system response regulator CreB	-
GV224_RS21370	4473911..4474333	-	423	WP_047570653.1	protein YgfX	Toxin
GV224_RS21375	4474314..4474580	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
GV224_RS21380	4474901..4475893	+	993	WP_047570651.1	tRNA-modifying protein YgfZ	-
GV224_RS21385	4475932..4476429	-	498	WP_033649451.1	DUF2165 domain-containing protein	-
GV224_RS21390	4476580..4477254	-	675	WP_033639467.1	hemolysin III family protein	-
GV224_RS21395	4477438..4478046	+	609	WP_047570649.1	HD domain-containing protein	-
GV224_RS21400	4478087..4479013	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4467855..4526295	58440

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16457.56 Da
• Isoelectric Point: 10.8114

>T147296 WP_047570653.1 NZ_CP047688:c4474333-4473911 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLSHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T147296 NZ_CP062901:182865-182972 [Escherichia coli O152:H23]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT147296 WP_004931679.1 NZ_CP047688:c4474580-4474314 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT147296 NZ_CP062901:c182816-182753 [Escherichia coli O152:H23]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT