Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4058938..4059594 Replicon chromosome
Accession NZ_CP047688
Organism Serratia marcescens strain 1140-

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GV224_RS19370 Protein ID WP_033648839.1
Coordinates 4058938..4059327 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag GV224_RS19375 Protein ID WP_004941563.1
Coordinates 4059331..4059594 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV224_RS19355 4055405..4056835 + 1431 WP_160866766.1 MFS transporter -
GV224_RS19360 4056832..4058214 + 1383 WP_094860007.1 two-component system sensor histidine kinase BaeS -
GV224_RS19365 4058214..4058930 + 717 WP_033635542.1 two-component system response regulator BaeR -
GV224_RS19370 4058938..4059327 - 390 WP_033648839.1 type II toxin-antitoxin system VapC family toxin Toxin
GV224_RS19375 4059331..4059594 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GV224_RS19380 4059934..4060272 + 339 WP_094860008.1 YegP family protein -
GV224_RS19385 4060453..4061805 + 1353 WP_033635545.1 tRNA 5-hydroxyuridine modification protein YegQ -
GV224_RS19390 4062272..4063177 + 906 WP_033635546.1 lipid kinase YegS -
GV224_RS19395 4063344..4064558 + 1215 WP_094860009.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14277.50 Da        Isoelectric Point: 7.8786

>T147293 WP_033648839.1 NZ_CP047688:c4059327-4058938 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSVVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T147293 NZ_CP062900:c133276-132971 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT147293 WP_004941563.1 NZ_CP047688:c4059594-4059331 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT147293 NZ_CP062900:c133496-133278 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References