Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3982861..3983498 Replicon chromosome
Accession NZ_CP047688
Organism Serratia marcescens strain 1140-

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GV224_RS19030 Protein ID WP_049191603.1
Coordinates 3983223..3983498 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GV224_RS19025 Protein ID WP_094888665.1
Coordinates 3982861..3983226 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV224_RS19010 3979489..3980580 + 1092 WP_094887884.1 phage portal protein -
GV224_RS19015 3981031..3981609 + 579 WP_094888669.1 sce7726 family protein -
GV224_RS19020 3981569..3982669 - 1101 WP_094888667.1 beta family protein -
GV224_RS19025 3982861..3983226 - 366 WP_094888665.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GV224_RS19030 3983223..3983498 - 276 WP_049191603.1 type II toxin-antitoxin system HicA family toxin Toxin
GV224_RS19035 3983568..3984263 - 696 WP_060417685.1 DNA adenine methylase -
GV224_RS19040 3984412..3986895 - 2484 WP_094887886.1 replication endonuclease -
GV224_RS26555 3986895..3987431 - 537 WP_201751705.1 hypothetical protein -
GV224_RS19050 3987428..3987697 - 270 WP_094887887.1 DUF3850 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3956909..3991886 34977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10099.70 Da        Isoelectric Point: 10.6115

>T147292 WP_049191603.1 NZ_CP047688:c3983498-3983223 [Serratia marcescens]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Download         Length: 276 bp

>T147292 NZ_CP062900:94750-95148 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13315.04 Da        Isoelectric Point: 4.5702

>AT147292 WP_094888665.1 NZ_CP047688:c3983226-3982861 [Serratia marcescens]
MTKTAAVTPNTMEIAGQPAIISYVPEIGTFRGKFLGLSGYCDFVSDSIQGLKAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVDTLNERMKHA

Download         Length: 366 bp

>AT147292 NZ_CP062900:94523-94750 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References