Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3300147..3300778 Replicon chromosome
Accession NZ_CP047688
Organism Serratia marcescens strain 1140-

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag GV224_RS15820 Protein ID WP_033640020.1
Coordinates 3300147..3300545 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag GV224_RS15825 Protein ID WP_041035628.1
Coordinates 3300545..3300778 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV224_RS15800 3295247..3296062 - 816 WP_047571544.1 5'-nucleotidase, lipoprotein e(P4) family -
GV224_RS15805 3296391..3296795 - 405 WP_047571543.1 flagellar protein FlhE -
GV224_RS15810 3296795..3298873 - 2079 WP_033635001.1 flagellar biosynthesis protein FlhA -
GV224_RS15815 3298866..3300017 - 1152 WP_015378261.1 flagellar type III secretion system protein FlhB -
GV224_RS15820 3300147..3300545 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
GV224_RS15825 3300545..3300778 - 234 WP_041035628.1 antitoxin Antitoxin
GV224_RS15830 3300904..3301548 - 645 WP_004934858.1 protein phosphatase CheZ -
GV224_RS15835 3301559..3301948 - 390 WP_004934862.1 chemotaxis response regulator CheY -
GV224_RS15840 3302051..3303100 - 1050 WP_033635003.1 chemotaxis response regulator protein-glutamate methylesterase -
GV224_RS15845 3303100..3303972 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
GV224_RS15850 3304010..3305626 - 1617 Protein_3096 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T147290 WP_033640020.1 NZ_CP047688:c3300545-3300147 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T147290 NZ_CP062900:c75653-75372 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT147290 WP_041035628.1 NZ_CP047688:c3300778-3300545 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT147290 NZ_CP062900:c75919-75650 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGGCAGACCGTTGAACAGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References