Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4232172..4232809 Replicon chromosome
Accession NZ_CP047685
Organism Serratia marcescens strain 2838

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GV198_RS20210 Protein ID WP_049191603.1
Coordinates 4232534..4232809 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GV198_RS20205 Protein ID WP_094888665.1
Coordinates 4232172..4232537 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV198_RS20190 4228800..4229891 + 1092 WP_094887884.1 phage portal protein -
GV198_RS20195 4230342..4230920 + 579 WP_094888669.1 sce7726 family protein -
GV198_RS20200 4230880..4231980 - 1101 WP_094888667.1 beta family protein -
GV198_RS20205 4232172..4232537 - 366 WP_094888665.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GV198_RS20210 4232534..4232809 - 276 WP_049191603.1 type II toxin-antitoxin system HicA family toxin Toxin
GV198_RS20215 4232879..4233574 - 696 WP_060417685.1 DNA adenine methylase -
GV198_RS20220 4233723..4236206 - 2484 WP_094887886.1 replication endonuclease -
GV198_RS26495 4236206..4236742 - 537 WP_201751705.1 hypothetical protein -
GV198_RS20230 4236739..4237008 - 270 WP_094887887.1 DUF3850 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4202332..4268120 65788


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10099.70 Da        Isoelectric Point: 10.6115

>T147272 WP_049191603.1 NZ_CP047685:c4232809-4232534 [Serratia marcescens]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Download         Length: 276 bp

>T147272 NZ_CP062895:910488-910895 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13315.04 Da        Isoelectric Point: 4.5702

>AT147272 WP_094888665.1 NZ_CP047685:c4232537-4232172 [Serratia marcescens]
MTKTAAVTPNTMEIAGQPAIISYVPEIGTFRGKFLGLSGYCDFVSDSIQGLKAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVDTLNERMKHA

Download         Length: 366 bp

>AT147272 NZ_CP062895:910241-910507 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References