Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3982528..3983165 Replicon chromosome
Accession NZ_CP047685
Organism Serratia marcescens strain 2838

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GV198_RS19015 Protein ID WP_049191603.1
Coordinates 3982890..3983165 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GV198_RS19010 Protein ID WP_094888665.1
Coordinates 3982528..3982893 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV198_RS18995 3979156..3980247 + 1092 WP_094887884.1 phage portal protein -
GV198_RS19000 3980698..3981276 + 579 WP_094888669.1 sce7726 family protein -
GV198_RS19005 3981236..3982336 - 1101 WP_094888667.1 beta family protein -
GV198_RS19010 3982528..3982893 - 366 WP_094888665.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GV198_RS19015 3982890..3983165 - 276 WP_049191603.1 type II toxin-antitoxin system HicA family toxin Toxin
GV198_RS19020 3983235..3983930 - 696 WP_060417685.1 DNA adenine methylase -
GV198_RS19025 3984079..3986562 - 2484 WP_094887886.1 replication endonuclease -
GV198_RS26485 3986562..3987098 - 537 WP_201751705.1 hypothetical protein -
GV198_RS19035 3987095..3987364 - 270 WP_094887887.1 DUF3850 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3956576..4028249 71673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10099.70 Da        Isoelectric Point: 10.6115

>T147270 WP_049191603.1 NZ_CP047685:c3983165-3982890 [Serratia marcescens]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Download         Length: 276 bp

>T147270 NZ_CP062895:725472-725768 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13315.04 Da        Isoelectric Point: 4.5702

>AT147270 WP_094888665.1 NZ_CP047685:c3982893-3982528 [Serratia marcescens]
MTKTAAVTPNTMEIAGQPAIISYVPEIGTFRGKFLGLSGYCDFVSDSIQGLKAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVDTLNERMKHA

Download         Length: 366 bp

>AT147270 NZ_CP062895:725770-726165 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References