Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1176540..1177161 Replicon chromosome
Accession NZ_CP047685
Organism Serratia marcescens strain 2838

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag GV198_RS05565 Protein ID WP_004940313.1
Coordinates 1176540..1176743 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag GV198_RS05570 Protein ID WP_004940312.1
Coordinates 1176793..1177161 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV198_RS05540 1172326..1172772 + 447 WP_047568994.1 type II secretion system protein M -
GV198_RS05545 1172808..1173623 + 816 WP_052133456.1 A24 family peptidase -
GV198_RS05550 1173620..1173982 - 363 WP_033653248.1 type II secretion system pilot lipoprotein GspS -
GV198_RS05555 1174236..1175672 + 1437 WP_047568993.1 N-acetylglucosamine-binding protein GbpA -
GV198_RS05560 1175725..1176243 + 519 WP_047568991.1 cytochrome b/b6 domain-containing protein -
GV198_RS05565 1176540..1176743 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
GV198_RS05570 1176793..1177161 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
GV198_RS05575 1177320..1177673 - 354 WP_033653245.1 hypothetical protein -
GV198_RS05580 1178081..1178794 + 714 WP_047568987.1 ABC transporter ATP-binding protein -
GV198_RS05585 1178791..1179648 + 858 WP_033637343.1 metal ABC transporter permease -
GV198_RS05590 1179674..1180552 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
GV198_RS05595 1180659..1180799 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
GV198_RS05600 1180812..1181066 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T147259 WP_004940313.1 NZ_CP047685:c1176743-1176540 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T147259 NZ_CP062890:c61685-61305 [Escherichia coli O100:H21]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT147259 WP_004940312.1 NZ_CP047685:c1177161-1176793 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT147259 NZ_CP062890:c61906-61685 [Escherichia coli O100:H21]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References