Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55602..56137 Replicon chromosome
Accession NZ_CP047685
Organism Serratia marcescens strain 2838

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D971
Locus tag GV198_RS00245 Protein ID WP_033636570.1
Coordinates 55862..56137 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D6BJ42
Locus tag GV198_RS00240 Protein ID WP_047569919.1
Coordinates 55602..55862 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV198_RS00220 50922..51572 + 651 WP_033649530.1 DcrB-related protein -
GV198_RS00225 51613..52218 + 606 WP_047569924.1 glutathione S-transferase -
GV198_RS00230 52287..53681 + 1395 WP_047569922.1 L-seryl-tRNA(Sec) selenium transferase -
GV198_RS00235 53678..55519 + 1842 WP_047569921.1 selenocysteine-specific translation elongation factor -
GV198_RS00240 55602..55862 + 261 WP_047569919.1 ribbon-helix-helix domain-containing protein Antitoxin
GV198_RS00245 55862..56137 + 276 WP_033636570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GV198_RS00250 56149..57060 - 912 WP_033636572.1 LysR family transcriptional regulator -
GV198_RS00255 57182..57808 + 627 WP_047569917.1 LysE family translocator -
GV198_RS00260 57859..59106 - 1248 WP_047571709.1 MFS transporter -
GV198_RS00265 59324..60316 + 993 WP_047569913.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10578.32 Da        Isoelectric Point: 10.3377

>T147256 WP_033636570.1 NZ_CP047685:55862-56137 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T147256 NZ_CP062889:4159515-4159889 [Escherichia coli O100:H21]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9683.98 Da        Isoelectric Point: 4.5084

>AT147256 WP_047569919.1 NZ_CP047685:55602-55862 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT147256 NZ_CP062889:4159057-4159425 [Escherichia coli O100:H21]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D971

Antitoxin

Source ID Structure
AlphaFold DB A0A7D6BJ42

References