Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2376787..2377418 Replicon chromosome
Accession NZ_CP047682
Organism Serratia marcescens strain 3024

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag GV218_RS11115 Protein ID WP_033640020.1
Coordinates 2377020..2377418 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag GV218_RS11110 Protein ID WP_041035628.1
Coordinates 2376787..2377020 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV218_RS11085 2371939..2373555 + 1617 Protein_2153 Tar ligand binding domain-containing protein -
GV218_RS11090 2373593..2374465 + 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
GV218_RS11095 2374465..2375514 + 1050 WP_033635003.1 chemotaxis response regulator protein-glutamate methylesterase -
GV218_RS11100 2375617..2376006 + 390 WP_004934862.1 chemotaxis response regulator CheY -
GV218_RS11105 2376017..2376661 + 645 WP_004934858.1 protein phosphatase CheZ -
GV218_RS11110 2376787..2377020 + 234 WP_041035628.1 antitoxin Antitoxin
GV218_RS11115 2377020..2377418 + 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
GV218_RS11120 2377548..2378699 + 1152 WP_015378261.1 flagellar type III secretion system protein FlhB -
GV218_RS11125 2378692..2380770 + 2079 WP_033635001.1 flagellar biosynthesis protein FlhA -
GV218_RS11130 2380770..2381174 + 405 WP_047571543.1 flagellar protein FlhE -
GV218_RS11135 2381503..2382318 + 816 WP_047571544.1 5'-nucleotidase, lipoprotein e(P4) family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T147242 WP_033640020.1 NZ_CP047682:2377020-2377418 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T147242 NZ_CP062889:1280710-1281108 [Escherichia coli O100:H21]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT147242 WP_041035628.1 NZ_CP047682:2376787-2377020 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT147242 NZ_CP062889:1280483-1280710 [Escherichia coli O100:H21]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References