Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1617972..1618628 Replicon chromosome
Accession NZ_CP047682
Organism Serratia marcescens strain 3024

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GV218_RS07565 Protein ID WP_033648839.1
Coordinates 1618239..1618628 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag GV218_RS07560 Protein ID WP_004941563.1
Coordinates 1617972..1618235 (+) Length 88 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV218_RS07540 1613008..1614222 - 1215 WP_094860009.1 D-galactonate dehydratase family protein -
GV218_RS07545 1614389..1615294 - 906 WP_033635546.1 lipid kinase YegS -
GV218_RS07550 1615761..1617113 - 1353 WP_033635545.1 tRNA 5-hydroxyuridine modification protein YegQ -
GV218_RS07555 1617294..1617632 - 339 WP_094860008.1 YegP family protein -
GV218_RS07560 1617972..1618235 + 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GV218_RS07565 1618239..1618628 + 390 WP_033648839.1 type II toxin-antitoxin system VapC family toxin Toxin
GV218_RS07570 1618636..1619352 - 717 WP_033635542.1 two-component system response regulator BaeR -
GV218_RS07575 1619352..1620734 - 1383 WP_094860007.1 two-component system sensor histidine kinase BaeS -
GV218_RS07580 1620731..1622161 - 1431 WP_160866766.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-119)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 130 a.a.        Molecular weight: 14277.50 Da        Isoelectric Point: 7.8786

>T147239 WP_033648839.1 NZ_CP047682:1618239-1618628 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSVVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T147239 NZ_CP062889:c587281-586817 [Escherichia coli O100:H21]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT147239 WP_004941563.1 NZ_CP047682:1617972-1618235 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT147239 NZ_CP062889:c587616-587281 [Escherichia coli O100:H21]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References