Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1444424..1445061 Replicon chromosome
Accession NZ_CP047682
Organism Serratia marcescens strain 3024

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GV218_RS06710 Protein ID WP_049191603.1
Coordinates 1444424..1444699 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GV218_RS06715 Protein ID WP_094888665.1
Coordinates 1444696..1445061 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV218_RS06690 1440225..1440494 + 270 WP_094887887.1 DUF3850 domain-containing protein -
GV218_RS26460 1440491..1441027 + 537 WP_201751705.1 hypothetical protein -
GV218_RS06700 1441027..1443510 + 2484 WP_094887886.1 replication endonuclease -
GV218_RS06705 1443659..1444354 + 696 WP_060417685.1 DNA adenine methylase -
GV218_RS06710 1444424..1444699 + 276 WP_049191603.1 type II toxin-antitoxin system HicA family toxin Toxin
GV218_RS06715 1444696..1445061 + 366 WP_094888665.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GV218_RS06720 1445253..1446353 + 1101 WP_094888667.1 beta family protein -
GV218_RS06725 1446313..1446891 - 579 WP_094888669.1 sce7726 family protein -
GV218_RS06730 1447342..1448433 - 1092 WP_094887884.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1435496..1471757 36261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10099.70 Da        Isoelectric Point: 10.6115

>T147238 WP_049191603.1 NZ_CP047682:1444424-1444699 [Serratia marcescens]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Download         Length: 276 bp

>T147238 NZ_CP062889:265367-265642 [Escherichia coli O100:H21]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13315.04 Da        Isoelectric Point: 4.5702

>AT147238 WP_094888665.1 NZ_CP047682:1444696-1445061 [Serratia marcescens]
MTKTAAVTPNTMEIAGQPAIISYVPEIGTFRGKFLGLSGYCDFVSDSIQGLKAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAENEVSVNAFIVDTLNERMKHA

Download         Length: 366 bp

>AT147238 NZ_CP062889:265639-265998 [Escherichia coli O100:H21]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References