Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4545381..4546038 Replicon chromosome
Accession NZ_CP047675
Organism Klebsiella pneumoniae subsp. pneumoniae strain KUH-KPNHVF1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GO010_RS21195 Protein ID WP_002916310.1
Coordinates 4545381..4545791 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GO010_RS21200 Protein ID WP_002916312.1
Coordinates 4545772..4546038 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO010_RS21175 4541381..4543114 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
GO010_RS21180 4543120..4543833 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GO010_RS21185 4543856..4544752 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GO010_RS21190 4544853..4545374 + 522 WP_002916308.1 flavodoxin FldB -
GO010_RS21195 4545381..4545791 - 411 WP_002916310.1 protein YgfX Toxin
GO010_RS21200 4545772..4546038 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GO010_RS21205 4546284..4547267 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
GO010_RS21210 4547366..4548025 - 660 WP_002916317.1 hemolysin III family protein -
GO010_RS21215 4548189..4548500 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GO010_RS21220 4548550..4549278 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GO010_RS21225 4549397..4550830 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T147208 WP_002916310.1 NZ_CP047675:c4545791-4545381 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T147208 NZ_CP062883:194912-195019 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT147208 WP_002916312.1 NZ_CP047675:c4546038-4545772 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT147208 NZ_CP062883:c194863-194800 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References