Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1269698..1270317 Replicon chromosome
Accession NZ_CP047675
Organism Klebsiella pneumoniae subsp. pneumoniae strain KUH-KPNHVF1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GO010_RS05950 Protein ID WP_002892050.1
Coordinates 1269698..1269916 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GO010_RS05955 Protein ID WP_002892066.1
Coordinates 1269943..1270317 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO010_RS05920 1265745..1266008 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
GO010_RS05925 1266008..1266148 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GO010_RS05930 1266145..1266843 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
GO010_RS05935 1266944..1268395 + 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
GO010_RS05940 1268370..1268840 - 471 WP_002892026.1 YlaC family protein -
GO010_RS26600 1268861..1269001 + 141 WP_004147370.1 hypothetical protein -
GO010_RS05945 1268973..1269539 - 567 WP_002892030.1 maltose O-acetyltransferase -
GO010_RS05950 1269698..1269916 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GO010_RS05955 1269943..1270317 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GO010_RS05960 1270803..1273949 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GO010_RS05965 1273972..1275165 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T147198 WP_002892050.1 NZ_CP047675:c1269916-1269698 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T147198 NZ_CP062879:c53194-53042 [Escherichia coli O157:H16]
ATGAGGAAGCGAGGTGGCGTCAGAGTGATTTACTACGTTCGCCTTGCCAGCGGCAGATTATACCTGCTTCTGATATACCC
TAAGAATGCTAAAGATGATCTTAGCGAGAAAGAAAAAGCCGTTATGAAGGTATTAGCACAGCAGCTGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT147198 WP_002892066.1 NZ_CP047675:c1270317-1269943 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT147198 NZ_CP062879:c52993-52697 [Escherichia coli O157:H16]
ATGGAAAAGAAACTTTTTGATGCACTTATTAGCAGCATGGAGGAAATGGTTGCCATTGAGAATGGCCAAATCCAGCCAGC
TGAAGAAAATGTTCACCGCCATACACTGCCGGATGTGAAGGCTATTCGTAAACATGCCGGAATGAAACAGGCTGAATTTG
CAGAAGTGGTGGGAGCCAGCGTTGACCTTATCCGCAGCTGGGAACAGAAACGGCGTATCCCGTCGGGTATTGCGTTGAAA
ATGCTCTGTCTCATCGAACGTGAGCCAGCACTGATTAATACCTTGCGCAGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References