Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 512635..513151 Replicon chromosome
Accession NZ_CP047675
Organism Klebsiella pneumoniae subsp. pneumoniae strain KUH-KPNHVF1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag GO010_RS02425 Protein ID WP_004178374.1
Coordinates 512867..513151 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GO010_RS02420 Protein ID WP_002886901.1
Coordinates 512635..512877 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO010_RS02405 508663..509403 + 741 WP_002886899.1 KDGP aldolase family protein -
GO010_RS02410 509470..510624 + 1155 WP_012737230.1 lactonase family protein -
GO010_RS02415 510647..512557 + 1911 WP_012737231.1 BglG family transcription antiterminator -
GO010_RS02420 512635..512877 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GO010_RS02425 512867..513151 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GO010_RS02430 513155..513619 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GO010_RS02435 513948..516086 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GO010_RS02440 516443..517186 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GO010_RS26530 517189..517362 - 174 WP_041169004.1 hypothetical protein -
GO010_RS02445 517447..517755 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T147196 WP_004178374.1 NZ_CP047675:512867-513151 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T147196 NZ_CP062877:59791-59943 [Escherichia coli O157:H16]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT147196 WP_002886901.1 NZ_CP047675:512635-512877 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT147196 NZ_CP062877:c59736-59679 [Escherichia coli O157:H16]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References