Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 151287..151926 Replicon chromosome
Accession NZ_CP047673
Organism Planococcus halotolerans strain Y50

Toxin (Protein)


Gene name pemK Uniprot ID A0A2I0FNF6
Locus tag DNR44_RS00770 Protein ID WP_033543552.1
Coordinates 151287..151637 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DNR44_RS00775 Protein ID WP_112224163.1
Coordinates 151642..151926 (-) Length 95 a.a.

Genomic Context

DNR44_RS00790DNR44_RS00735DNR44_RS00740DNR44_RS00745DNR44_RS00750DNR44_RS00755DNR44_RS00760DNR44_RS00765DNR44_RS00770DNR44_RS00775DNR44_RS00780DNR44_RS00785DNR44_RS00795DNR44_RS00800
Location: 153582..154184 (603 bp)
Type: Others
Protein ID: WP_112224161.1
Location: 146797..147579 (783 bp)
Type: Others
Protein ID: WP_112224167.1
Location: 147557..148027 (471 bp)
Type: Others
Protein ID: WP_033543558.1
Location: 148029..148358 (330 bp)
Type: Others
Protein ID: WP_112224166.1
Location: 148469..149470 (1002 bp)
Type: Others
Protein ID: WP_112224165.1
Location: 149483..149884 (402 bp)
Type: Others
Protein ID: WP_071152218.1
Location: 149887..150249 (363 bp)
Type: Others
Protein ID: WP_071152217.1
Location: 150246..151076 (831 bp)
Type: Others
Protein ID: WP_112224164.1
Location: 151287..151637 (351 bp)
Type: Toxin
Protein ID: WP_033543552.1
Location: 151642..151926 (285 bp)
Type: Antitoxin
Protein ID: WP_112224163.1
Location: 152028..153143 (1116 bp)
Type: Others
Protein ID: WP_112224183.1
Location: 153127..153513 (387 bp)
Type: Others
Protein ID: WP_112224162.1
Location: 154412..155941 (1530 bp)
Type: Others
Protein ID: WP_112224182.1
Location: 155934..156413 (480 bp)
Type: Others
Protein ID: WP_112224181.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DNR44_RS00735 (DNR44_000730)146797..147579-783WP_112224167.1RNA polymerase sigma factor SigB-
DNR44_RS00740 (DNR44_000735)147557..148027-471WP_033543558.1anti-sigma B factor RsbW-
DNR44_RS00745 (DNR44_000740)148029..148358-330WP_112224166.1anti-sigma factor antagonist-
DNR44_RS00750 (DNR44_000745)148469..149470-1002WP_112224165.1PP2C family protein-serine/threonine phosphatase-
DNR44_RS00755 (DNR44_000750)149483..149884-402WP_071152218.1anti-sigma regulatory factor-
DNR44_RS00760 (DNR44_000755)149887..150249-363WP_071152217.1STAS domain-containing protein-
DNR44_RS00765 (DNR44_000760)150246..151076-831WP_112224164.1RsbT co-antagonist protein RsbRA-
DNR44_RS00770 (DNR44_000765)151287..151637-351WP_033543552.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DNR44_RS00775 (DNR44_000770)151642..151926-285WP_112224163.1transcriptional regulatorAntitoxin
DNR44_RS00780 (DNR44_000775)152028..153143-1116WP_112224183.1alanine racemase-
DNR44_RS00785 (DNR44_000780)153127..153513-387WP_112224162.1holo-ACP synthase-
DNR44_RS00790 (DNR44_000785)153582..154184+603WP_112224161.1rhomboid family intramembrane serine protease-
DNR44_RS00795 (DNR44_000790)154412..155941-1530WP_112224182.1PH domain-containing protein-
DNR44_RS00800 (DNR44_000795)155934..156413-480WP_112224181.1PH domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12865.96 Da        Isoelectric Point: 5.2065

>T147194 WP_033543552.1 NZ_CP047673:c151637-151287 [Planococcus halotolerans]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDEALMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T147194 NZ_CP062876:4117201-4117512 [Escherichia coli O157:H16]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10872.32 Da        Isoelectric Point: 5.5804

>AT147194 WP_112224163.1 NZ_CP047673:c151926-151642 [Planococcus halotolerans]
VYERSKTKEVVVKLPKQLISELTTHSDERVQEDGDYIYVSTQRVMKNMYDSNHIREAMIKGYVEMSQINLSISCECSHVE
YEAEHMTVRLVSGG

Download         Length: 285 bp

>AT147194 NZ_CP062876:4117509-4117928 [Escherichia coli O157:H16]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2I0FNF6

Antitoxin

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Source
ID
Structure
No matching records found

References