Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/MazF(toxin) |
| Location | 151287..151926 | Replicon | chromosome |
| Accession | NZ_CP047673 | ||
| Organism | Planococcus halotolerans strain Y50 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | A0A2I0FNF6 |
| Locus tag | DNR44_RS00770 | Protein ID | WP_033543552.1 |
| Coordinates | 151287..151637 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | DNR44_RS00775 | Protein ID | WP_112224163.1 |
| Coordinates | 151642..151926 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DNR44_RS00735 (DNR44_000730) | 146797..147579 | - | 783 | WP_112224167.1 | RNA polymerase sigma factor SigB | - |
| DNR44_RS00740 (DNR44_000735) | 147557..148027 | - | 471 | WP_033543558.1 | anti-sigma B factor RsbW | - |
| DNR44_RS00745 (DNR44_000740) | 148029..148358 | - | 330 | WP_112224166.1 | anti-sigma factor antagonist | - |
| DNR44_RS00750 (DNR44_000745) | 148469..149470 | - | 1002 | WP_112224165.1 | PP2C family protein-serine/threonine phosphatase | - |
| DNR44_RS00755 (DNR44_000750) | 149483..149884 | - | 402 | WP_071152218.1 | anti-sigma regulatory factor | - |
| DNR44_RS00760 (DNR44_000755) | 149887..150249 | - | 363 | WP_071152217.1 | STAS domain-containing protein | - |
| DNR44_RS00765 (DNR44_000760) | 150246..151076 | - | 831 | WP_112224164.1 | RsbT co-antagonist protein RsbRA | - |
| DNR44_RS00770 (DNR44_000765) | 151287..151637 | - | 351 | WP_033543552.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| DNR44_RS00775 (DNR44_000770) | 151642..151926 | - | 285 | WP_112224163.1 | transcriptional regulator | Antitoxin |
| DNR44_RS00780 (DNR44_000775) | 152028..153143 | - | 1116 | WP_112224183.1 | alanine racemase | - |
| DNR44_RS00785 (DNR44_000780) | 153127..153513 | - | 387 | WP_112224162.1 | holo-ACP synthase | - |
| DNR44_RS00790 (DNR44_000785) | 153582..154184 | + | 603 | WP_112224161.1 | rhomboid family intramembrane serine protease | - |
| DNR44_RS00795 (DNR44_000790) | 154412..155941 | - | 1530 | WP_112224182.1 | PH domain-containing protein | - |
| DNR44_RS00800 (DNR44_000795) | 155934..156413 | - | 480 | WP_112224181.1 | PH domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12865.96 Da Isoelectric Point: 5.2065
>T147194 WP_033543552.1 NZ_CP047673:c151637-151287 [Planococcus halotolerans]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDEALMEKVDEALEISVGLVKF
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDEALMEKVDEALEISVGLVKF
Download Length: 351 bp
>T147194 NZ_CP062876:4117201-4117512 [Escherichia coli O157:H16]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10872.32 Da Isoelectric Point: 5.5804
>AT147194 WP_112224163.1 NZ_CP047673:c151926-151642 [Planococcus halotolerans]
VYERSKTKEVVVKLPKQLISELTTHSDERVQEDGDYIYVSTQRVMKNMYDSNHIREAMIKGYVEMSQINLSISCECSHVE
YEAEHMTVRLVSGG
VYERSKTKEVVVKLPKQLISELTTHSDERVQEDGDYIYVSTQRVMKNMYDSNHIREAMIKGYVEMSQINLSISCECSHVE
YEAEHMTVRLVSGG
Download Length: 285 bp
>AT147194 NZ_CP062876:4117509-4117928 [Escherichia coli O157:H16]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|