Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3468897..3469489 Replicon chromosome
Accession NZ_CP047671
Organism Edwardsiella piscicida strain CK41

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag GT752_RS15955 Protein ID WP_012847872.1
Coordinates 3468897..3469100 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D0ZEC3
Locus tag GT752_RS15960 Protein ID WP_012847873.1
Coordinates 3469121..3469489 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT752_RS15925 (GT752_15785) 3464562..3465023 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
GT752_RS15930 (GT752_15790) 3465328..3465666 + 339 WP_012847867.1 P-II family nitrogen regulator -
GT752_RS15935 (GT752_15795) 3465688..3466968 + 1281 WP_041692495.1 ammonium transporter AmtB -
GT752_RS15940 (GT752_15800) 3467003..3467869 - 867 WP_012847869.1 acyl-CoA thioesterase II -
GT752_RS15945 (GT752_15805) 3467978..3468307 - 330 WP_225857588.1 MGMT family protein -
GT752_RS15955 (GT752_15815) 3468897..3469100 - 204 WP_012847872.1 HHA domain-containing protein Toxin
GT752_RS15960 (GT752_15820) 3469121..3469489 - 369 WP_012847873.1 Hha toxicity modulator TomB Antitoxin
GT752_RS15965 (GT752_15825) 3469857..3473006 - 3150 Protein_3082 efflux RND transporter permease subunit -
GT752_RS15970 (GT752_15830) 3473050..3474234 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T147192 WP_012847872.1 NZ_CP047671:c3469100-3468897 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T147192 NZ_CP062876:3909025-3909432 [Escherichia coli O157:H16]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14129.83 Da        Isoelectric Point: 6.1484

>AT147192 WP_012847873.1 NZ_CP047671:c3469489-3469121 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNATLHV

Download         Length: 369 bp

>AT147192 NZ_CP062876:3908778-3909044 [Escherichia coli O157:H16]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB D0ZEC3

References