Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1853815..1854614 Replicon chromosome
Accession NZ_CP047671
Organism Edwardsiella piscicida strain CK41

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GT752_RS08585 Protein ID WP_041692550.1
Coordinates 1854081..1854614 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GT752_RS08580 Protein ID WP_041692549.1
Coordinates 1853815..1854084 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT752_RS08545 (GT752_08455) 1849394..1850110 + 717 WP_012849890.1 SprT family zinc-dependent metalloprotease -
GT752_RS08550 (GT752_08460) 1850355..1850894 + 540 WP_012849891.1 transposase DNA-binding-containing protein -
GT752_RS08555 (GT752_08465) 1850908..1851705 + 798 Protein_1664 IS21 family transposase -
GT752_RS08560 (GT752_08470) 1851942..1852157 - 216 WP_012849893.1 PapB/FocB family fimbrial expression transcriptional regulator -
GT752_RS08565 (GT752_08475) 1852169..1852432 - 264 WP_041692548.1 DUF2442 domain-containing protein -
GT752_RS08570 (GT752_08480) 1852392..1852631 - 240 WP_012849894.1 DUF4160 domain-containing protein -
GT752_RS08575 (GT752_08485) 1853125..1853721 + 597 WP_071818540.1 helix-turn-helix domain-containing protein -
GT752_RS08580 (GT752_08490) 1853815..1854084 + 270 WP_041692549.1 DUF1778 domain-containing protein Antitoxin
GT752_RS08585 (GT752_08495) 1854081..1854614 + 534 WP_041692550.1 GNAT family N-acetyltransferase Toxin
GT752_RS08590 (GT752_08500) 1854712..1855455 - 744 WP_012849897.1 hypothetical protein -
GT752_RS08595 (GT752_08505) 1857453..1857704 + 252 Protein_1672 IS21 family transposase -
GT752_RS08600 (GT752_08510) 1857701..1858483 + 783 WP_012846920.1 IS21-like element ISSen3 family helper ATPase IstB -
GT752_RS08605 (GT752_08515) 1858588..1859391 + 804 WP_012849899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1811958..1867604 55646
- flank IS/Tn - - 1850908..1851789 881
- flank IS/Tn - - 1857704..1858483 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19938.93 Da        Isoelectric Point: 7.0275

>T147191 WP_041692550.1 NZ_CP047671:1854081-1854614 [Edwardsiella piscicida]
MNSGTEFKELSKADHDRDSFDCGEIELNNFIKNFALKHMRVGISKTMVLPATDALPNNKHPICAFYTVAPSSITRNSLPD
DLGKKLPHYPVPVFLLAQLSVHIDNQGDGLGKITLIKALEYLWNVNYFLHAYAVVVDCLNDKAESFYRKYGFETLCSYDG
RVRLFLPMKTVAGLFSD

Download         Length: 534 bp

>T147191 NZ_CP062876:3753080-3753376 [Escherichia coli O157:H16]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9827.37 Da        Isoelectric Point: 7.1662

>AT147191 WP_041692549.1 NZ_CP047671:1853815-1854084 [Edwardsiella piscicida]
MATARLDLRLDPEIKAKAEKASALLGLKTLTEYIVHIVDNDAKRVIAAHESMALPNDIFDQFMNACEQAKEPNSALKSAL
SFTREKGIK

Download         Length: 270 bp

>AT147191 NZ_CP062876:3753378-3753773 [Escherichia coli O157:H16]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References