Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1701875..1702538 Replicon chromosome
Accession NZ_CP047671
Organism Edwardsiella piscicida strain CK41

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag GT752_RS07895 Protein ID WP_034167931.1
Coordinates 1701875..1702291 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag GT752_RS07900 Protein ID WP_012849755.1
Coordinates 1702272..1702538 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT752_RS07875 (GT752_07790) 1697806..1699539 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
GT752_RS07880 (GT752_07795) 1699544..1700260 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GT752_RS07885 (GT752_07800) 1700288..1701187 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
GT752_RS07890 (GT752_07805) 1701338..1701850 + 513 WP_012849753.1 flavodoxin FldB -
GT752_RS07895 (GT752_07810) 1701875..1702291 - 417 WP_034167931.1 protein YgfX Toxin
GT752_RS07900 (GT752_07815) 1702272..1702538 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
GT752_RS07905 (GT752_07820) 1702892..1703890 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
GT752_RS07910 (GT752_07825) 1703932..1704756 - 825 WP_012849757.1 shikimate 5-dehydrogenase -
GT752_RS07915 (GT752_07830) 1704915..1705787 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
GT752_RS07920 (GT752_07835) 1706396..1707045 + 650 Protein_1538 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T147189 WP_034167931.1 NZ_CP047671:c1702291-1701875 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T147189 NZ_CP062876:3292403-3292678 [Escherichia coli O157:H16]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT147189 WP_012849755.1 NZ_CP047671:c1702538-1702272 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT147189 NZ_CP062876:3292675-3293034 [Escherichia coli O157:H16]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References