Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1519001..1519596 Replicon chromosome
Accession NZ_CP047670
Organism Alcaligenes faecalis strain SCSIO B001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTU60_RS06840 Protein ID WP_086068963.1
Coordinates 1519291..1519596 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GTU60_RS06835 Protein ID WP_086068933.1
Coordinates 1519001..1519294 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU60_RS06815 1514673..1514960 - 288 WP_199265835.1 tyrosine-type recombinase/integrase -
GTU60_RS06820 1515433..1516386 + 954 WP_199265595.1 tripartite tricarboxylate transporter substrate binding protein -
GTU60_RS06825 1516415..1517383 + 969 WP_063692921.1 tripartite tricarboxylate transporter substrate binding protein -
GTU60_RS06830 1517395..1518696 + 1302 WP_199265596.1 sulfatase-like hydrolase/transferase -
GTU60_RS06835 1519001..1519294 - 294 WP_086068933.1 putative addiction module antidote protein Antitoxin
GTU60_RS06840 1519291..1519596 - 306 WP_086068963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTU60_RS06845 1519785..1520783 + 999 WP_199265597.1 taurine ABC transporter substrate-binding protein -
GTU60_RS06850 1520789..1521574 + 786 WP_199265598.1 taurine ABC transporter ATP-binding subunit -
GTU60_RS06855 1521633..1522481 + 849 WP_199265836.1 taurine ABC transporter permease TauC -
GTU60_RS06860 1522530..1523234 - 705 WP_199265599.1 SDR family oxidoreductase -
GTU60_RS06865 1523338..1524234 + 897 WP_199265600.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11464.21 Da        Isoelectric Point: 10.2270

>T147179 WP_086068963.1 NZ_CP047670:c1519596-1519291 [Alcaligenes faecalis]
MNTINRTEAFNTWLSGLKDLRARAKIVIRIKQASLGNFGDVKPISDGVCEMRIHFGPGYRLYYAREGRVVYLLLSGGDKS
SQKQDIKTAIAMWKQIQEDQS

Download         Length: 306 bp

>T147179 NZ_CP062876:325380-325483 [Escherichia coli O157:H16]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10310.87 Da        Isoelectric Point: 4.8359

>AT147179 WP_086068933.1 NZ_CP047670:c1519294-1519001 [Alcaligenes faecalis]
MTTIKTAPFDAAEYLDSEEAIAEYLSAALEEDDPALFLSALADVVKARGMTKMAKDAGVGRESLYKALAPGAKPRYDTVL
KLARAAGVKLTVEPIHA

Download         Length: 294 bp

>AT147179 NZ_CP062876:c325521-325250 [Escherichia coli O157:H16]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References