Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3256197..3256854 Replicon chromosome
Accession NZ_CP047669
Organism Klebsiella aerogenes strain HNHF1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag GUU79_RS16955 Protein ID WP_015369792.1
Coordinates 3256197..3256607 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag GUU79_RS16960 Protein ID WP_015369791.1
Coordinates 3256588..3256854 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU79_RS16935 3252196..3253929 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
GUU79_RS16940 3253935..3254648 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GUU79_RS16945 3254671..3255567 - 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
GUU79_RS16950 3255668..3256189 + 522 WP_015369793.1 flavodoxin FldB -
GUU79_RS16955 3256197..3256607 - 411 WP_015369792.1 protein YgfX Toxin
GUU79_RS16960 3256588..3256854 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
GUU79_RS16965 3257078..3258061 + 984 WP_015703421.1 tRNA-modifying protein YgfZ -
GUU79_RS16970 3258160..3258819 - 660 WP_008806429.1 hemolysin III family protein -
GUU79_RS16975 3258984..3259295 - 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
GUU79_RS16980 3259346..3260080 + 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
GUU79_RS16985 3260194..3261627 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T147177 WP_015369792.1 NZ_CP047669:c3256607-3256197 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T147177 NZ_CP062876:107463-107714 [Escherichia coli O157:H16]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAAATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT147177 WP_015369791.1 NZ_CP047669:c3256854-3256588 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT147177 NZ_CP062876:107711-107965 [Escherichia coli O157:H16]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References