Detailed information of TA system TA147176

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2912253..2913036
• Replicon: chromosome
• Accession: NZ_CP047669
• Organism: Klebsiella aerogenes strain HNHF1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: GUU79_RS15280
• Protein ID: WP_167353669.1
• Coordinates: 2912668..2913036 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: GUU79_RS15275
• Protein ID: WP_040018969.1
• Coordinates: 2912253..2912612 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GUU79_RS15235	2907470..2908327	+	858	WP_032705139.1	hypothetical protein	-
GUU79_RS15240	2908605..2909069	+	465	WP_004114621.1	hypothetical protein	-
GUU79_RS15245	2909124..2909483	+	360	WP_004114622.1	hypothetical protein	-
GUU79_RS15250	2909569..2909781	+	213	WP_094354213.1	hypothetical protein	-
GUU79_RS15255	2909892..2910713	+	822	WP_004114624.1	DUF945 domain-containing protein	-
GUU79_RS15260	2910793..2911272	+	480	WP_094354212.1	antirestriction protein	-
GUU79_RS15265	2911513..2911995	+	483	WP_094354211.1	DNA repair protein RadC	-
GUU79_RS15270	2912009..2912230	+	222	WP_004114632.1	DUF987 domain-containing protein	-
GUU79_RS15275	2912253..2912612	+	360	WP_040018969.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GUU79_RS15280	2912668..2913036	+	369	WP_167353669.1	TA system toxin CbtA family protein	Toxin
GUU79_RS15285	2913116..2913436	-	321	WP_004114640.1	hypothetical protein	-
GUU79_RS15290	2913575..2914564	-	990	WP_160184205.1	glycosyltransferase	-
GUU79_RS15295	2915187..2916104	-	918	WP_004114644.1	hypothetical protein	-
GUU79_RS15300	2916149..2917093	+	945	WP_199660085.1	bacteriophage abortive infection AbiH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2890240..2940326	50086

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.52 Da
• Isoelectric Point: 9.4643

>T147176 WP_167353669.1 NZ_CP047669:2912668-2913036 [Klebsiella aerogenes]
IQSLPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQSPFIGSLDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 369 bp

>T147176 NZ_CP062874:c93301-93143 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13349.56 Da
• Isoelectric Point: 8.1516

>AT147176 WP_040018969.1 NZ_CP047669:2912253-2912612 [Klebsiella aerogenes]
MKKATRIINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDTDLRHLDQAFPVLMKQMELMLASSELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSAITA

Nucleotide

• Length: 360 bp

>AT147176 NZ_CP062874:c93569-93345 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT