Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 423313..423908 Replicon chromosome
Accession NZ_CP047662
Organism Escherichia coli strain LD93-1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag GUU84_RS01965 Protein ID WP_000239579.1
Coordinates 423558..423908 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag GUU84_RS01960 Protein ID WP_001223208.1
Coordinates 423313..423564 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU84_RS01950 418977..422756 + 3780 WP_021557470.1 autotransporter assembly complex protein TamB -
GUU84_RS01955 422759..423100 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
GUU84_RS01960 423313..423564 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
GUU84_RS01965 423558..423908 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
GUU84_RS01970 423988..424518 - 531 WP_000055072.1 inorganic diphosphatase -
GUU84_RS01975 424828..425784 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
GUU84_RS01980 425924..427426 + 1503 WP_021557471.1 sugar ABC transporter ATP-binding protein -
GUU84_RS01985 427440..428462 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T147106 WP_000239579.1 NZ_CP047662:423558-423908 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T147106 NZ_CP062865:c1888864-1888757 [Escherichia coli O39:H21]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT147106 WP_001223208.1 NZ_CP047662:423313-423564 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT147106 NZ_CP062865:1888912-1888979 [Escherichia coli O39:H21]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References