Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 132312..132906 Replicon plasmid pLD39-1-134kb
Accession NZ_CP047660
Organism Escherichia coli strain LD39-1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag GUU82_RS24560 Protein ID WP_001403920.1
Coordinates 132631..132906 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID G3CAJ1
Locus tag GUU82_RS24555 Protein ID WP_001261274.1
Coordinates 132312..132542 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU82_RS24535 127446..128252 - 807 WP_000016982.1 site-specific integrase -
GUU82_RS24540 128253..128558 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
GUU82_RS24545 128560..128778 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
GUU82_RS24550 129492..132113 + 2622 WP_000283688.1 histidinol-phosphatase -
GUU82_RS24555 132312..132542 + 231 WP_001261274.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GUU82_RS24560 132631..132906 + 276 WP_001403920.1 type II toxin-antitoxin system VapC family toxin Toxin
GUU82_RS24565 132911..133128 - 218 Protein_129 transposase -
GUU82_RS24570 133129..133659 - 531 WP_000348883.1 GNAT family N-acetyltransferase -
GUU82_RS24575 133663..133932 - 270 WP_001275013.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..134831 134831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 9621.03 Da        Isoelectric Point: 8.5444

>T147104 WP_001403920.1 NZ_CP047660:132631-132906 [Escherichia coli]
VFSHRIVVSAITYSEMRFGASGPKASPRHVQLVDKFCPCLDAILSWDRAAVDGTTDIKVALRQAGTPIGQNDTAIAGPEA
GRLGKLTSPTL

Download         Length: 276 bp

>T147104 NZ_CP062865:c1887794-1887687 [Escherichia coli O39:H21]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8856.95 Da        Isoelectric Point: 4.6286

>AT147104 WP_001261274.1 NZ_CP047660:132312-132542 [Escherichia coli]
MRTVSIFKNGNNRAIHLPRDLDFERVRELEIVREGDSIILRPVQPNWGSFAQLEKADPDFMAERENVVSDEGRFDL

Download         Length: 231 bp

>AT147104 NZ_CP062865:1887842-1887908 [Escherichia coli O39:H21]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G3CAJ1

References