Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3144428..3145133 Replicon chromosome
Accession NZ_CP047658
Organism Escherichia coli strain LD39-1

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag GUU82_RS15275 Protein ID WP_000539521.1
Coordinates 3144428..3144814 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GUU82_RS15280 Protein ID WP_001280945.1
Coordinates 3144804..3145133 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU82_RS15255 3140432..3141058 + 627 WP_001295292.1 glutathione S-transferase GstB -
GUU82_RS15260 3141055..3142170 - 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
GUU82_RS15265 3142281..3142664 - 384 WP_000497137.1 biofilm formation regulator BssR -
GUU82_RS15270 3142877..3144202 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
GUU82_RS15275 3144428..3144814 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUU82_RS15280 3144804..3145133 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
GUU82_RS15285 3145203..3146531 - 1329 WP_000086877.1 GGDEF domain-containing protein -
GUU82_RS15290 3146539..3148887 - 2349 WP_112022350.1 EAL domain-containing protein -
GUU82_RS15295 3149065..3149976 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T147091 WP_000539521.1 NZ_CP047658:3144428-3144814 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T147091 NZ_CP062863:2643594-2643701 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT147091 WP_001280945.1 NZ_CP047658:3144804-3145133 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT147091 NZ_CP062863:c2643547-2643481 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References