Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2619643..2621203 Replicon chromosome
Accession NZ_CP047656
Organism Paraglaciecola mesophila strain GPM4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FX988_RS11130 Protein ID WP_160179869.1
Coordinates 2619643..2620941 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FX988_RS11135 Protein ID WP_160179871.1
Coordinates 2620943..2621203 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX988_RS11110 2615929..2617143 + 1215 WP_160179863.1 AGE family epimerase/isomerase -
FX988_RS11115 2617326..2618693 - 1368 WP_160179865.1 DUF839 domain-containing protein -
FX988_RS11120 2618862..2619050 - 189 WP_160179867.1 hypothetical protein -
FX988_RS11130 2619643..2620941 - 1299 WP_160179869.1 type II toxin-antitoxin system HipA family toxin Toxin
FX988_RS11135 2620943..2621203 - 261 WP_160179871.1 helix-turn-helix domain-containing protein Antitoxin
FX988_RS11140 2621575..2622558 - 984 WP_160179872.1 transposase -
FX988_RS11145 2623012..2624139 + 1128 WP_160179874.1 hypothetical protein -
FX988_RS11150 2624360..2625286 - 927 WP_160179876.1 bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase -
FX988_RS11155 2625382..2625819 - 438 WP_160179878.1 D-tyrosyl-tRNA(Tyr) deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-396)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48398.58 Da        Isoelectric Point: 8.9277

>T147070 WP_160179869.1 NZ_CP047656:c2620941-2619643 [Paraglaciecola mesophila]
MQLLVSLNGVKVGILLKDKSGGLHFSYTEQWMKRVGARPISLSLPITKQKYTGDLVYNFFDNLLPDNPNIRNKIQIRFNV
GSGHAFDLLAAIGKDCVGAIQLSSEQPESVNQLNYKMLSDQNVEKLLQGYKHTALGMEGDDDDFRISIAGAQEKTALLKI
GQQWAKPIGSTPTSHIMKLPMGELPQVGIDLTDSCENEFICLELARAFGFNVANSEVLYFGDQKVLSVERFDRKYASDGS
WLMRLPQEDFCQAMGISSAQKYQSDGGPGITDCLSLLTASSNRKDRATFFKTQIFFWLIAAIDGHGKNFSVFLEPENTYR
MTPLYDVLSAFPVMLKSASKKTLQPQKIKMAMSLKGKNTHWKWNDIQPRHFVSTAKYVKYPSDKAASHYEYFIDNVENAI
TQVEGKIPTNFPPYVAEAIFSGLRKQAAKKLL

Download         Length: 1299 bp

>T147070 NZ_CP062857:c43089-42808 [Escherichia coli O20:H12]
ATGACCTATGAACTGGCTTTTGACAGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGCGCATCTGGCTACAGACTTGTATATCAAGTTATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTCTACCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9803.04 Da        Isoelectric Point: 7.3188

>AT147070 WP_160179871.1 NZ_CP047656:c2621203-2620943 [Paraglaciecola mesophila]
MKLNNSKELADYIKLHRNKLARTQTDVAEHVGLKQKTISAIENSAGNTRIDTLFKIAHELGLSIELKPKQVNESDQKTES
GWDQEW

Download         Length: 261 bp

>AT147070 NZ_CP062857:c43330-43079 [Escherichia coli O20:H12]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCCGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References