Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2619643..2621203 Replicon chromosome
Accession NZ_CP047656
Organism Paraglaciecola mesophila strain GPM4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FX988_RS11130 Protein ID WP_160179869.1
Coordinates 2619643..2620941 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FX988_RS11135 Protein ID WP_160179871.1
Coordinates 2620943..2621203 (-) Length 87 a.a.

Genomic Context

FX988_RS11110FX988_RS11145FX988_RS11115FX988_RS11120FX988_RS11130FX988_RS11135FX988_RS11140FX988_RS11150FX988_RS11155
Location: 2615929..2617143 (1215 bp)
Type: Others
Protein ID: WP_160179863.1
Location: 2623012..2624139 (1128 bp)
Type: Others
Protein ID: WP_160179874.1
Location: 2617326..2618693 (1368 bp)
Type: Others
Protein ID: WP_160179865.1
Location: 2618862..2619050 (189 bp)
Type: Others
Protein ID: WP_160179867.1
Location: 2619643..2620941 (1299 bp)
Type: Toxin
Protein ID: WP_160179869.1
Location: 2620943..2621203 (261 bp)
Type: Antitoxin
Protein ID: WP_160179871.1
Location: 2621575..2622558 (984 bp)
Type: Others
Protein ID: WP_160179872.1
Location: 2624360..2625286 (927 bp)
Type: Others
Protein ID: WP_160179876.1
Location: 2625382..2625819 (438 bp)
Type: Others
Protein ID: WP_160179878.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FX988_RS111102615929..2617143+1215WP_160179863.1AGE family epimerase/isomerase-
FX988_RS111152617326..2618693-1368WP_160179865.1DUF839 domain-containing protein-
FX988_RS111202618862..2619050-189WP_160179867.1hypothetical protein-
FX988_RS111302619643..2620941-1299WP_160179869.1type II toxin-antitoxin system HipA family toxinToxin
FX988_RS111352620943..2621203-261WP_160179871.1helix-turn-helix domain-containing proteinAntitoxin
FX988_RS111402621575..2622558-984WP_160179872.1transposase-
FX988_RS111452623012..2624139+1128WP_160179874.1hypothetical protein-
FX988_RS111502624360..2625286-927WP_160179876.1bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase-
FX988_RS111552625382..2625819-438WP_160179878.1D-tyrosyl-tRNA(Tyr) deacylase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-396)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48398.58 Da        Isoelectric Point: 8.9277

>T147070 WP_160179869.1 NZ_CP047656:c2620941-2619643 [Paraglaciecola mesophila]
MQLLVSLNGVKVGILLKDKSGGLHFSYTEQWMKRVGARPISLSLPITKQKYTGDLVYNFFDNLLPDNPNIRNKIQIRFNV
GSGHAFDLLAAIGKDCVGAIQLSSEQPESVNQLNYKMLSDQNVEKLLQGYKHTALGMEGDDDDFRISIAGAQEKTALLKI
GQQWAKPIGSTPTSHIMKLPMGELPQVGIDLTDSCENEFICLELARAFGFNVANSEVLYFGDQKVLSVERFDRKYASDGS
WLMRLPQEDFCQAMGISSAQKYQSDGGPGITDCLSLLTASSNRKDRATFFKTQIFFWLIAAIDGHGKNFSVFLEPENTYR
MTPLYDVLSAFPVMLKSASKKTLQPQKIKMAMSLKGKNTHWKWNDIQPRHFVSTAKYVKYPSDKAASHYEYFIDNVENAI
TQVEGKIPTNFPPYVAEAIFSGLRKQAAKKLL

Download         Length: 1299 bp

>T147070 NZ_CP062857:c43089-42808 [Escherichia coli O20:H12]
ATGACCTATGAACTGGCTTTTGACAGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGCGCATCTGGCTACAGACTTGTATATCAAGTTATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTCTACCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9803.04 Da        Isoelectric Point: 7.3188

>AT147070 WP_160179871.1 NZ_CP047656:c2621203-2620943 [Paraglaciecola mesophila]
MKLNNSKELADYIKLHRNKLARTQTDVAEHVGLKQKTISAIENSAGNTRIDTLFKIAHELGLSIELKPKQVNESDQKTES
GWDQEW

Download         Length: 261 bp

>AT147070 NZ_CP062857:c43330-43079 [Escherichia coli O20:H12]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCCGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References