Detailed information of TA system TA147069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 860852..861380
• Replicon: chromosome
• Accession: NZ_CP047656
• Organism: Paraglaciecola mesophila strain GPM4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FX988_RS03550
• Protein ID: WP_160178373.1
• Coordinates: 861093..861380 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FX988_RS03545
• Protein ID: WP_160178372.1
• Coordinates: 860852..861103 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX988_RS03525	856871..857842	+	972	WP_201751629.1	alpha/beta hydrolase	-
FX988_RS03530	857877..858017	+	141	Protein_695	IS4 family transposase	-
FX988_RS03535	858111..859094	+	984	WP_160178370.1	transposase	-
FX988_RS03540	859353..859952	-	600	WP_160178371.1	hypothetical protein	-
FX988_RS03545	860852..861103	+	252	WP_160178372.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FX988_RS03550	861093..861380	+	288	WP_160178373.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FX988_RS03555	861414..862345	-	932	Protein_700	IS110 family transposase	-
FX988_RS03560	862686..863159	+	474	WP_160178374.1	hypothetical protein	-
FX988_RS03565	863160..863363	-	204	Protein_702	IS110 family transposase	-
FX988_RS03570	863526..864413	-	888	WP_160178375.1	nuclear transport factor 2 family protein	-
FX988_RS03575	864416..865504	-	1089	WP_160178376.1	nuclear transport factor 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	861414..861995	581

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-58)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11112.24 Da
• Isoelectric Point: 10.6025

>T147069 WP_160178373.1 NZ_CP047656:861093-861380 [Paraglaciecola mesophila]
MTYKLKFLPAAKKEWDKLAEPLKKQFKNKLAERLENPHVPSAKLRGYDSVYKIKLRTAGYRLAYEVVDKEIVIYVLTIGK
RDKNAIYKKLASRLV

Nucleotide

• Length: 288 bp

>T147069 NZ_CP062855:c4504106-4503933 [Escherichia coli O20:H12]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9205.42 Da
• Isoelectric Point: 4.1232

>AT147069 WP_160178372.1 NZ_CP047656:860852-861103 [Paraglaciecola mesophila]
MRQVLADFSASISELKKNPTALLTEADGSAIAILNHNKPAAYLVPAETYEWLMDVVDDYELAKIVDERRGDLSKAIEVNL
DDL

Nucleotide

• Length: 252 bp

>AT147069 NZ_CP062855:c4504430-4504134 [Escherichia coli O20:H12]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG