Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3350096..3350736 Replicon chromosome
Accession NZ_CP047650
Organism Xylophilus rhododendri strain KACC 21265

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GT347_RS15515 Protein ID WP_160553040.1
Coordinates 3350096..3350275 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GT347_RS15520 Protein ID WP_160553041.1
Coordinates 3350305..3350736 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT347_RS15495 3345735..3346706 - 972 WP_160553036.1 tripartite tricarboxylate transporter substrate binding protein -
GT347_RS15500 3346741..3347754 - 1014 WP_160553037.1 LacI family DNA-binding transcriptional regulator -
GT347_RS15505 3347751..3348518 - 768 WP_160553038.1 SDR family oxidoreductase -
GT347_RS15510 3348515..3349831 - 1317 WP_160553039.1 histidinol dehydrogenase -
GT347_RS15515 3350096..3350275 + 180 WP_160553040.1 type II toxin-antitoxin system HicA family toxin Toxin
GT347_RS15520 3350305..3350736 + 432 WP_160553041.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GT347_RS15525 3350748..3351047 - 300 WP_160553042.1 hypothetical protein -
GT347_RS15530 3351364..3351615 - 252 WP_160553043.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GT347_RS15535 3351782..3352864 + 1083 WP_160553044.1 hypothetical protein -
GT347_RS15540 3352951..3353484 + 534 WP_160553045.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
GT347_RS15545 3353481..3354467 + 987 WP_160553046.1 xanthine dehydrogenase family protein subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-65)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7035.19 Da        Isoelectric Point: 11.2353

>T147066 WP_160553040.1 NZ_CP047650:3350096-3350275 [Xylophilus rhododendri]
MKISEFKRWLEAEGVRIENGTRHWRLYFRGHCSTLPRHPSQELKEGTRRAILKQLGMKA

Download         Length: 180 bp

>T147066 NZ_CP062855:4147024-4147233 [Escherichia coli O20:H12]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15838.19 Da        Isoelectric Point: 5.7134

>AT147066 WP_160553041.1 NZ_CP047650:3350305-3350736 [Xylophilus rhododendri]
MTHRNYPASFEPDPDGGFVVTFRDIPEAITQGDTREEAESMAGDALITAMDFYFEEGRLVPPPTKARRREVLVALPLSVA
AKVELLNLVVQRKERPADLARAMGVKPQEVTRLLNLHHATKIDTLAAAFRALGGELELNIRFA

Download         Length: 432 bp

>AT147066 NZ_CP062855:c4147032-4146975 [Escherichia coli O20:H12]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References