Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2292690..2293231 Replicon chromosome
Accession NZ_CP047650
Organism Xylophilus rhododendri strain KACC 21265

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GT347_RS10590 Protein ID WP_160551918.1
Coordinates 2292899..2293231 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GT347_RS10585 Protein ID WP_160551917.1
Coordinates 2292690..2292899 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT347_RS10555 2288273..2289022 + 750 WP_160551912.1 BON domain-containing protein -
GT347_RS10560 2289024..2289965 - 942 WP_160551913.1 ROK family protein -
GT347_RS10565 2290039..2290233 - 195 WP_160551914.1 DUF2905 domain-containing protein -
GT347_RS10570 2290243..2291394 - 1152 WP_160551915.1 SAM-dependent methyltransferase -
GT347_RS10575 2291412..2292226 + 815 Protein_2085 SDR family oxidoreductase -
GT347_RS10580 2292256..2292627 + 372 WP_160551916.1 dihydroneopterin aldolase -
GT347_RS10585 2292690..2292899 + 210 WP_160551917.1 DUF3018 family protein Antitoxin
GT347_RS10590 2292899..2293231 + 333 WP_160551918.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GT347_RS10595 2293256..2294194 + 939 WP_160551919.1 tRNA 2-thiocytidine(32) synthetase TtcA -
GT347_RS10600 2294220..2294849 + 630 WP_160551920.1 DUF4136 domain-containing protein -
GT347_RS10605 2294939..2295580 + 642 WP_160551921.1 histidine phosphatase family protein -
GT347_RS10610 2295839..2296765 + 927 WP_160551922.1 hypothetical protein -
GT347_RS10615 2296784..2297848 - 1065 WP_160551923.1 Holliday junction branch migration DNA helicase RuvB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin

Antitoxin MazE-like

(11-54)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11648.59 Da        Isoelectric Point: 7.9919

>T147065 WP_160551918.1 NZ_CP047650:2292899-2293231 [Xylophilus rhododendri]
MAEVKRGDVVAVSLQGDFGKPRPALVVQADGLAGLGSVVVCPLTSDLRDAPLFRVTVEPDRANGLKSLSQVMVDKISTLP
RDKLGEAFGSLNADRMRAVERAMFVVLGLA

Download         Length: 333 bp

>T147065 NZ_CP062855:3672648-3672866 [Escherichia coli O20:H12]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7656.52 Da        Isoelectric Point: 6.7158

>AT147065 WP_160551917.1 NZ_CP047650:2292690-2292899 [Xylophilus rhododendri]
MNHPHSESQDAVARHRESRRAAGLKLKQVWVPDTRSALFAEELERQCRAVGDDGLAFAEAAAQALDGWK

Download         Length: 210 bp

>AT147065 NZ_CP062855:3672248-3672622 [Escherichia coli O20:H12]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References