Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1449717..1450300 Replicon chromosome
Accession NZ_CP047650
Organism Xylophilus rhododendri strain KACC 21265

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GT347_RS06540 Protein ID WP_160551196.1
Coordinates 1450109..1450300 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GT347_RS06535 Protein ID WP_160551195.1
Coordinates 1449717..1450106 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT347_RS06510 1445040..1445414 - 375 WP_160551190.1 response regulator transcription factor -
GT347_RS06515 1445611..1446168 + 558 WP_160551191.1 fasciclin domain-containing protein -
GT347_RS06520 1446196..1447023 - 828 WP_160551192.1 helix-turn-helix transcriptional regulator -
GT347_RS06525 1447175..1448398 + 1224 WP_160551193.1 MFS transporter -
GT347_RS06530 1448450..1449652 + 1203 WP_160551194.1 HAMP domain-containing histidine kinase -
GT347_RS06535 1449717..1450106 - 390 WP_160551195.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GT347_RS06540 1450109..1450300 - 192 WP_160551196.1 type II toxin-antitoxin system HicA family toxin Toxin
GT347_RS06545 1450370..1450786 - 417 WP_160551197.1 YbaN family protein -
GT347_RS06550 1450943..1452814 + 1872 WP_160551198.1 AAA family ATPase -
GT347_RS06555 1452952..1453524 + 573 WP_160551199.1 DUF3455 domain-containing protein -
GT347_RS06560 1453551..1454138 + 588 WP_160551200.1 sigma-70 family RNA polymerase sigma factor -
GT347_RS06565 1454135..1454887 + 753 WP_160551201.1 anti-sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-121)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7228.53 Da        Isoelectric Point: 11.4246

>T147064 WP_160551196.1 NZ_CP047650:c1450300-1450109 [Xylophilus rhododendri]
VDSKQIVRRLLAEGWVKVAVVGSHTKFKLPGRMNHVVVPHPKKDLPIGTVRSIYRQAGWQWKE

Download         Length: 192 bp

>T147064 NZ_CP062855:2829125-2829232 [Escherichia coli O20:H12]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14451.15 Da        Isoelectric Point: 4.4999

>AT147064 WP_160551195.1 NZ_CP047650:c1450106-1449717 [Xylophilus rhododendri]
MFFPAYVHKDEDSSYGLTFPDFEGCFAAADSLQDLPQAAQDAVQAHFEGETFAIPKATAPERWVGDERFEGGYWMLVEID
LSRINPKAIRINVSMSEQLVHEIDQFANAHQMSRSAFLAVASREKLAHA

Download         Length: 390 bp

>AT147064 NZ_CP062855:c2829069-2829013 [Escherichia coli O20:H12]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References