Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4881553..4882069 Replicon chromosome
Accession NZ_CP047649
Organism Klebsiella pneumoniae strain 158590

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GTK59_RS23800 Protein ID WP_002886902.1
Coordinates 4881553..4881837 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GTK59_RS23805 Protein ID WP_002886901.1
Coordinates 4881827..4882069 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK59_RS23780 4877037..4877345 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
GTK59_RS27010 4877430..4877603 + 174 WP_002886906.1 hypothetical protein -
GTK59_RS23785 4877606..4878349 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GTK59_RS23790 4878706..4880844 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
GTK59_RS23795 4881085..4881549 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GTK59_RS23800 4881553..4881837 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTK59_RS23805 4881827..4882069 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTK59_RS23810 4882147..4884057 - 1911 WP_004152270.1 BglG family transcription antiterminator -
GTK59_RS23815 4884080..4885234 - 1155 WP_002886900.1 lactonase family protein -
GTK59_RS23820 4885300..4886040 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T147060 WP_002886902.1 NZ_CP047649:c4881837-4881553 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T147060 NZ_CP062855:1860711-1860965 [Escherichia coli O20:H12]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT147060 WP_002886901.1 NZ_CP047649:c4882069-4881827 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT147060 NZ_CP062855:1860463-1860714 [Escherichia coli O20:H12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References