Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1511443..1512062 Replicon chromosome
Accession NZ_CP047648
Organism Klebsiella pneumoniae strain 156070

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GTK58_RS07600 Protein ID WP_002892050.1
Coordinates 1511443..1511661 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GTK58_RS07605 Protein ID WP_002892066.1
Coordinates 1511688..1512062 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK58_RS07570 1507490..1507753 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
GTK58_RS07575 1507753..1507893 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GTK58_RS07580 1507890..1508588 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
GTK58_RS07585 1508689..1510140 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GTK58_RS07590 1510115..1510585 - 471 WP_002892026.1 YlaC family protein -
GTK58_RS26425 1510606..1510746 + 141 WP_004147370.1 hypothetical protein -
GTK58_RS07595 1510718..1511284 - 567 WP_002892030.1 maltose O-acetyltransferase -
GTK58_RS07600 1511443..1511661 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GTK58_RS07605 1511688..1512062 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GTK58_RS07610 1512548..1515694 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
GTK58_RS07615 1515717..1516910 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T147031 WP_002892050.1 NZ_CP047648:c1511661-1511443 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T147031 NZ_CP062853:856865-857272 [Escherichia coli O9:H10]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT147031 WP_002892066.1 NZ_CP047648:c1512062-1511688 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT147031 NZ_CP062853:856618-856884 [Escherichia coli O9:H10]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References