Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 187585..188165 Replicon chromosome
Accession NZ_CP047647
Organism Hymenobacter busanensis strain BT182

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GUY19_RS00840 Protein ID WP_151080479.1
Coordinates 187585..187845 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GUY19_RS00845 Protein ID WP_151080480.1
Coordinates 187833..188165 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY19_RS00805 182621..183052 - 432 WP_160619864.1 HNH endonuclease -
GUY19_RS00810 183172..184407 - 1236 WP_151080475.1 hypothetical protein -
GUY19_RS00820 184834..185463 + 630 WP_151080476.1 hypothetical protein -
GUY19_RS00825 185751..186044 + 294 WP_151080477.1 helix-turn-helix domain-containing protein -
GUY19_RS00830 186041..186301 + 261 WP_151080478.1 hypothetical protein -
GUY19_RS20625 187270..187566 - 297 WP_201743868.1 hypothetical protein -
GUY19_RS00840 187585..187845 + 261 WP_151080479.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
GUY19_RS00845 187833..188165 + 333 WP_151080480.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
GUY19_RS00850 188327..188917 - 591 WP_151080481.1 hypothetical protein -
GUY19_RS00855 188933..189976 - 1044 WP_151080482.1 caspase family protein -
GUY19_RS00860 189984..190430 - 447 WP_151080483.1 hypothetical protein -
GUY19_RS00865 191469..193001 + 1533 WP_151080484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 163119..194566 31447


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(6-108)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9796.01 Da        Isoelectric Point: 4.5800

>T147025 WP_151080479.1 NZ_CP047647:187585-187845 [Hymenobacter busanensis]
MNTRLIRVGNSQGIVLPKKLLQQYHLAGEVDLQPTPEGLLIKPVSKPRRQGWDEQFQHALAQGQAPEGELLEGFSDEAFE
ETDWQW

Download         Length: 261 bp

>T147025 NZ_CP062851:3650784-3651062 [Escherichia coli O9:H10]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12597.50 Da        Isoelectric Point: 9.7072

>AT147025 WP_151080480.1 NZ_CP047647:187833-188165 [Hymenobacter busanensis]
MAVVAVQRFEVWLINLDPTQGSEINKTRPCVVLSPDEMNRYLRTVTIAALTSTRRDYPSRVDCTFQGKAGQVALDHIRSV
DKTRFVRRLGVLSKTTAQQVCDRLQEIFHY

Download         Length: 333 bp

>AT147025 NZ_CP062851:3650521-3650781 [Escherichia coli O9:H10]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References