Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2726649..2727437 Replicon chromosome
Accession NZ_CP047646
Organism Staphylococcus aureus strain 19/Msa0875

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag GQ601_RS13220 Protein ID WP_000525004.1
Coordinates 2726649..2727110 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag GQ601_RS13225 Protein ID WP_000333630.1
Coordinates 2727123..2727437 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ601_RS13195 (GQ601_13255) 2721656..2723686 + 2031 WP_212593116.1 hypothetical protein -
GQ601_RS13200 (GQ601_13260) 2723729..2724934 - 1206 WP_000264751.1 site-specific integrase -
GQ601_RS13205 (GQ601_13265) 2725060..2725674 + 615 WP_000191459.1 hypothetical protein -
GQ601_RS13210 (GQ601_13270) 2725671..2725817 - 147 WP_001013104.1 hypothetical protein -
GQ601_RS13215 (GQ601_13275) 2726047..2726631 - 585 WP_000825948.1 hypothetical protein -
GQ601_RS13220 (GQ601_13280) 2726649..2727110 - 462 WP_000525004.1 hypothetical protein Toxin
GQ601_RS13225 (GQ601_13285) 2727123..2727437 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
GQ601_RS13230 (GQ601_13290) 2727589..2727825 + 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
GQ601_RS13235 (GQ601_13295) 2727839..2728615 + 777 WP_001148544.1 Rha family transcriptional regulator -
GQ601_RS13240 (GQ601_13300) 2728644..2728787 + 144 WP_000939498.1 hypothetical protein -
GQ601_RS13245 (GQ601_13305) 2728777..2728986 - 210 WP_000642492.1 hypothetical protein -
GQ601_RS13250 (GQ601_13310) 2729042..2729257 + 216 WP_001097552.1 hypothetical protein -
GQ601_RS13255 (GQ601_13315) 2729282..2729545 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
GQ601_RS13260 (GQ601_13320) 2729558..2729719 + 162 WP_001285954.1 DUF1270 domain-containing protein -
GQ601_RS13265 (GQ601_13325) 2729798..2730121 + 324 WP_000174998.1 hypothetical protein -
GQ601_RS13270 (GQ601_13330) 2730136..2730498 + 363 WP_000985972.1 hypothetical protein -
GQ601_RS13275 (GQ601_13335) 2730495..2731661 + 1167 WP_212593117.1 DUF2800 domain-containing protein -
GQ601_RS13280 (GQ601_13340) 2731688..2732245 + 558 WP_212593118.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T147024 WP_000525004.1 NZ_CP047646:c2727110-2726649 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T147024 NZ_CP062851:c3644730-3644332 [Escherichia coli O9:H10]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT147024 WP_000333630.1 NZ_CP047646:c2727437-2727123 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT147024 NZ_CP062851:c3645026-3644733 [Escherichia coli O9:H10]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References