Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2366358..2367134 Replicon chromosome
Accession NZ_CP047646
Organism Staphylococcus aureus strain 19/Msa0875

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag GQ601_RS11405 Protein ID WP_000031108.1
Coordinates 2366982..2367134 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag GQ601_RS11400 Protein ID WP_001251224.1
Coordinates 2366358..2366957 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ601_RS11380 (GQ601_11430) 2362274..2363731 + 1458 WP_000649908.1 ABC transporter permease subunit -
GQ601_RS11385 (GQ601_11435) 2363724..2364446 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
GQ601_RS11390 (GQ601_11440) 2364597..2365724 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
GQ601_RS11395 (GQ601_11445) 2365729..2366199 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GQ601_RS11400 (GQ601_11450) 2366358..2366957 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
GQ601_RS11405 (GQ601_11455) 2366982..2367134 + 153 WP_000031108.1 SAS053 family protein Toxin
GQ601_RS11410 (GQ601_11460) 2367677..2368072 + 396 WP_000901018.1 hypothetical protein -
GQ601_RS11415 (GQ601_11465) 2368268..2369653 + 1386 WP_000116238.1 class II fumarate hydratase -
GQ601_RS11420 (GQ601_11470) 2370108..2370929 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T147023 WP_000031108.1 NZ_CP047646:2366982-2367134 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T147023 NZ_CP062851:3425426-3425644 [Escherichia coli O9:H10]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT147023 WP_001251224.1 NZ_CP047646:2366358-2366957 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT147023 NZ_CP062851:3425026-3425400 [Escherichia coli O9:H10]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References