Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2185229..2185743 Replicon chromosome
Accession NZ_CP047646
Organism Staphylococcus aureus strain 19/Msa0875

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GQ601_RS10395 Protein ID WP_000581792.1
Coordinates 2185534..2185743 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GQ601_RS10390 Protein ID WP_000138932.1
Coordinates 2185229..2185522 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ601_RS10370 (GQ601_10420) 2180992..2182307 + 1316 Protein_2057 ISL3 family transposase -
GQ601_RS13540 2182285..2182347 - 63 Protein_2058 hypothetical protein -
GQ601_RS10380 (GQ601_10430) 2182904..2183551 - 648 WP_001187614.1 HD domain-containing protein -
GQ601_RS10385 (GQ601_10435) 2183579..2185063 - 1485 WP_000571550.1 cardiolipin synthase -
GQ601_RS10390 (GQ601_10440) 2185229..2185522 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GQ601_RS10395 (GQ601_10445) 2185534..2185743 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
GQ601_RS10400 (GQ601_10450) 2185871..2186008 + 138 WP_000828354.1 Lmo0850 family protein -
GQ601_RS10405 (GQ601_10455) 2186272..2187474 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
GQ601_RS10410 (GQ601_10460) 2187792..2188862 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
GQ601_RS10415 (GQ601_10465) 2188877..2190232 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147021 WP_000581792.1 NZ_CP047646:2185534-2185743 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147021 NZ_CP062851:2576962-2577069 [Escherichia coli O9:H10]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT147021 WP_000138932.1 NZ_CP047646:2185229-2185522 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147021 NZ_CP062851:c2576912-2576849 [Escherichia coli O9:H10]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References