Detailed information of TA system TA147014

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 698598..699074
• Replicon: chromosome
• Accession: NZ_CP047646
• Organism: Staphylococcus aureus strain 19/Msa0875

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: GQ601_RS03270
• Protein ID: WP_000052076.1
• Coordinates: 698886..699074 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: GQ601_RS03265
• Protein ID: WP_001059690.1
• Coordinates: 698598..698858 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQ601_RS03230 (GQ601_03270)	693996..694712	-	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-
GQ601_RS03235 (GQ601_03275)	694860..695282	+	423	WP_000974452.1	organic hydroperoxide resistance protein	-
GQ601_RS03240 (GQ601_03280)	695681..696175	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
GQ601_RS03245 (GQ601_03285)	696324..696941	+	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
GQ601_RS03250 (GQ601_03290)	697014..697595	-	582	WP_001140696.1	histidine phosphatase family protein	-
GQ601_RS03255 (GQ601_03295)	697820..698056	+	237	WP_000368687.1	hypothetical protein	-
GQ601_RS03260 (GQ601_03300)	698053..698256	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
GQ601_RS03265 (GQ601_03305)	698598..698858	+	261	WP_001059690.1	hypothetical protein	Antitoxin
GQ601_RS03270 (GQ601_03310)	698886..699074	+	189	WP_000052076.1	hypothetical protein	Toxin
GQ601_RS03275 (GQ601_03315)	699262..699831	+	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
GQ601_RS03280 (GQ601_03320)	699919..700203	+	285	WP_001004403.1	hypothetical protein	-
GQ601_RS03285 (GQ601_03325)	700264..700482	+	219	WP_000005881.1	hypothetical protein	-
GQ601_RS03290 (GQ601_03330)	700979..701179	-	201	WP_001059082.1	cold-shock protein	-
GQ601_RS03295 (GQ601_03335)	701536..702222	-	687	WP_001574556.1	thermonuclease family protein	-
GQ601_RS03300 (GQ601_03340)	702563..703045	-	483	WP_000824489.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T147014 WP_000052076.1 NZ_CP047646:698886-699074 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T147014 NZ_CP062851:1759499-1759753 [Escherichia coli O9:H10]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT147014 WP_001059690.1 NZ_CP047646:698598-698858 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT147014 NZ_CP062851:1759251-1759502 [Escherichia coli O9:H10]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56