Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3949246..3949885 Replicon chromosome
Accession NZ_CP047639
Organism Proteus sp. ZN5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GTK47_RS18235 Protein ID WP_165125839.1
Coordinates 3949481..3949885 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GTK47_RS18230 Protein ID WP_088493701.1
Coordinates 3949246..3949488 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK47_RS18210 3945212..3946177 + 966 WP_075672017.1 ribose ABC transporter permease -
GTK47_RS18215 3946220..3947110 + 891 WP_165125837.1 ribose ABC transporter substrate-binding protein RbsB -
GTK47_RS18220 3947189..3948115 + 927 WP_109401312.1 ribokinase -
GTK47_RS18225 3948120..3949127 + 1008 WP_206535869.1 ribose operon transcriptional repressor RbsR -
GTK47_RS18230 3949246..3949488 + 243 WP_088493701.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GTK47_RS18235 3949481..3949885 + 405 WP_165125839.1 type II toxin-antitoxin system VapC family toxin Toxin
GTK47_RS18240 3950324..3950659 + 336 WP_088493703.1 phnA family protein -
GTK47_RS18245 3950754..3951737 - 984 WP_165125841.1 thiamine-phosphate kinase -
GTK47_RS18250 3951841..3952254 - 414 WP_006535124.1 transcription antitermination factor NusB -
GTK47_RS18255 3952283..3952753 - 471 WP_023580887.1 6,7-dimethyl-8-ribityllumazine synthase -
GTK47_RS18260 3952966..3954120 - 1155 WP_165125843.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
GTK47_RS18265 3954191..3954640 - 450 WP_006535128.1 transcriptional regulator NrdR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15328.53 Da        Isoelectric Point: 7.4650

>T147003 WP_165125839.1 NZ_CP047639:3949481-3949885 [Proteus sp. ZN5]
MIKYLLDTNIVIFTIKRRPEFLLPKFNQYVEQLAISTITLAELLYGAEKSSNSAKNLATVNDFVSRLSVLPYDELAAFHY
GDIRATLEKQGKRIGDNELHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTHH

Download         Length: 405 bp

>T147003 NZ_CP062843:c75653-75372 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9316.41 Da        Isoelectric Point: 4.7969

>AT147003 WP_088493701.1 NZ_CP047639:3949246-3949488 [Proteus sp. ZN5]
MIQHGKVFMSNRTQNVRLPADTRFPDDVKDVVVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQVTSERESFDD

Download         Length: 243 bp

>AT147003 NZ_CP062843:c75919-75650 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGGCAGACCGTTGAACAGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References