Detailed information of TA system TA147002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2580595..2581394
• Replicon: chromosome
• Accession: NZ_CP047639
• Organism: Proteus sp. ZN5

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: GTK47_RS11880
• Protein ID: WP_165123407.1
• Coordinates: 2580870..2581394 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: GTK47_RS11875
• Protein ID: WP_165123405.1
• Coordinates: 2580595..2580873 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK47_RS11850	2575868..2576950	+	1083	WP_165123399.1	peptide chain release factor 1	-
GTK47_RS11855	2576950..2577798	+	849	WP_165123401.1	peptide chain release factor N(5)-glutamine methyltransferase	-
GTK47_RS11860	2577782..2578591	+	810	WP_165126595.1	invasion regulator SirB1	-
GTK47_RS11865	2578648..2579502	+	855	WP_088495432.1	3-deoxy-8-phosphooctulonate synthase	-
GTK47_RS11870	2579511..2580440	+	930	WP_165123403.1	TIGR01212 family radical SAM protein	-
GTK47_RS11875	2580595..2580873	+	279	WP_165123405.1	DUF1778 domain-containing protein	Antitoxin
GTK47_RS11880	2580870..2581394	+	525	WP_165123407.1	GNAT family N-acetyltransferase	Toxin
GTK47_RS11885	2581476..2583176	-	1701	WP_165123409.1	C4-dicarboxylic acid transporter DauA	-
GTK47_RS11895	2584162..2585103	+	942	WP_165123420.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19173.07 Da
• Isoelectric Point: 9.3466

>T147002 WP_165123407.1 NZ_CP047639:2580870-2581394 [Proteus sp. ZN5]
MTIPNWHEEAISKKHDRHTFNCGDTALNQFLYRHARQNHESGSSKTYLAINSSNNAIIGYYSLCPASIEFEKTPEIIKRG
LARHDIPVFRLARLATDLSVQGKGLGGQLLLTAGKRCLAVASELGGVALLIDAKNERVANWYISYGAVPLLDSPLSLLIS
FKTIYTALTMANKI

Nucleotide

• Length: 525 bp

>T147002 NZ_CP062842:65159-65311 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10310.95 Da
• Isoelectric Point: 6.3497

>AT147002 WP_165123405.1 NZ_CP047639:2580595-2580873 [Proteus sp. ZN5]
MAQTLVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNVVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDKV

Nucleotide

• Length: 279 bp

>AT147002 NZ_CP062842:c65104-65047 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT