Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 444401..445972 Replicon chromosome
Accession NZ_CP047639
Organism Proteus sp. ZN5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GTK47_RS02205 Protein ID WP_165121987.1
Coordinates 444659..445972 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GTK47_RS02200 Protein ID WP_072070485.1
Coordinates 444401..444658 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK47_RS02175 440370..440513 + 144 WP_036933424.1 50S ribosomal protein L34 -
GTK47_RS02180 440531..440890 + 360 WP_165121985.1 ribonuclease P protein component -
GTK47_RS02185 440854..441114 + 261 WP_072064717.1 membrane protein insertion efficiency factor YidD -
GTK47_RS02190 441117..442757 + 1641 WP_165121986.1 membrane protein insertase YidC -
GTK47_RS02195 442888..444252 + 1365 WP_023583363.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
GTK47_RS02200 444401..444658 + 258 WP_072070485.1 helix-turn-helix domain-containing protein Antitoxin
GTK47_RS02205 444659..445972 + 1314 WP_165121987.1 type II toxin-antitoxin system HipA family toxin Toxin
GTK47_RS02210 446170..446349 + 180 WP_088494147.1 hypothetical protein -
GTK47_RS02215 447133..447594 + 462 WP_165121988.1 DUF1097 domain-containing protein -
GTK47_RS02220 447695..448378 - 684 WP_165126436.1 ABC transporter ATP-binding protein -
GTK47_RS02225 448309..449226 - 918 WP_165121989.1 TonB-dependent receptor plug domain-containing protein -
GTK47_RS02230 449374..449838 - 465 WP_165121990.1 iron chelate uptake ABC transporter family permease subunit -
GTK47_RS02235 450110..450910 - 801 WP_165121991.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49571.39 Da        Isoelectric Point: 5.8252

>T147000 WP_165121987.1 NZ_CP047639:444659-445972 [Proteus sp. ZN5]
MASLDVYMNEYYVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLTAVGADTVGALRLLPSGSTPANIKKIEYNKLDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIVKTENIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIISIMNYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGQGLNSRDAKLAMGLQASRGKKYAIEQIFPRHFYQTAEAASFDPSLMTDILRYFYKEM
DDAIKRVKQQLPDDFPSEISNKILNGMKTRSARLANI

Download         Length: 1314 bp

>T147000 NZ_CP062840:c2570-1530 [Escherichia coli]
ATGGCACAGAACCCGTTTAAAGCACTAAATATCAATATTGACAAGATTGAGTCTGCTCTGACGCAGAATGGCGTCACAAA
CTATTCCTCTAATGTAAAAAACGAAAGAGAAACTCACATATCTGGCACATATAAAGGAATAGACTTCTTAATAAAACTAA
TGCCATCAGGCGGAAATACCACTATCGGAAGAGCGTCTGGGCAAAATAACACTTACTTTGATGAAATCGCCTTGATTATA
AAAGAAAACTGTTTGTATTCAGACACAAAGAACTTTGAATACACCATTCCAAAATTCAGTGATGATGACAGGGCAAATCT
ATTTGAATTTCTTTCTGAAGAGGGGATAACAATAACAGAAGATAATAATAACGATCCTAATTGTAAACACCAATATATTA
TGACCACCAGCAATGGTGACAGGGTCAGGGCAAAAATTTACAAGCGCGGCTCTATTCAATTCCAAGGAAAATACCTTCAA
ATCGCGAGTTTGATTAACGATTTCATGTGCTCAATACTAAACATGAAAGAGATTGTCGAACAAAAAAATAAAGAATTTAA
TGTTGACATAAAAAAAGAAACTATTGAGTCCGAGTTGCATAGCAAACTACCAAAAAGCATCGATAAAATCCATGAAGATA
TCAAAAAACAGCTATCATGCTCGCTAATAATGAAAAAAATAGATGTCGAAATGGAAGATTACTCAACATACTGCTTCTCT
GCATTAAGAGCTATAGAAGGCTTTATATATCAAATACTTAATGATGTTTGCAATCCATCATCATCAAAGAACCTTGGCGA
ATACTTCACTGAAAACAAACCCAAATATATAATCAGAGAAATACACCAAGAAACTATAAATGGTGAAATAGCGGAAGTTT
TGTGTGAATGCTACACTTACTGGCATGAGAACAGGCATGGTTTGTTTCATATGAAACCAGGAATAGCTGACACGAAGACA
ATTAACAAATTAGAATCAATCGCAATCATCGATACCGTTTGCCAATTAATAGATGGTGGCGTAGCTAGGTTGAAATTATG
A

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9848.40 Da        Isoelectric Point: 10.0139

>AT147000 WP_072070485.1 NZ_CP047639:444401-444658 [Proteus sp. ZN5]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT147000 NZ_CP062840:c1533-1153 [Escherichia coli]
ATGAAAAAAGATAAAAAATATCAAATAGAAGCAATAAAAAATAAAGATAAAACTTTATTTATTGTCTATGCTACTGATAT
TTATAGCCCGAGCGAATTTTTCTCAAAAATCGAATCCGACTTGAAGAAAAAGAAAAGCAAGGGTGATGTTTTTTTTGATT
TAATAATTCCTAACGGTGGAAAAAAAGATCGTTACGTCTATACGTCATTTAATGGCGAGAAGTTTTCAAGTTACACATTA
AACAAAGTTACGAAAACTGATGAATATAATGATTTATCTGAGCTCTCGGCTTCGTTCTTTAAAAAGAACTTTGATAAGAT
CAACGTAAACCTTCTATCCAAAGCCACATCATTTGCTTTGAAAAAAGGCATTCCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References