Detailed information of TA system TA147000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 444401..445972
• Replicon: chromosome
• Accession: NZ_CP047639
• Organism: Proteus sp. ZN5

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GTK47_RS02205
• Protein ID: WP_165121987.1
• Coordinates: 444659..445972 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GTK47_RS02200
• Protein ID: WP_072070485.1
• Coordinates: 444401..444658 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK47_RS02175	440370..440513	+	144	WP_036933424.1	50S ribosomal protein L34	-
GTK47_RS02180	440531..440890	+	360	WP_165121985.1	ribonuclease P protein component	-
GTK47_RS02185	440854..441114	+	261	WP_072064717.1	membrane protein insertion efficiency factor YidD	-
GTK47_RS02190	441117..442757	+	1641	WP_165121986.1	membrane protein insertase YidC	-
GTK47_RS02195	442888..444252	+	1365	WP_023583363.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
GTK47_RS02200	444401..444658	+	258	WP_072070485.1	helix-turn-helix domain-containing protein	Antitoxin
GTK47_RS02205	444659..445972	+	1314	WP_165121987.1	type II toxin-antitoxin system HipA family toxin	Toxin
GTK47_RS02210	446170..446349	+	180	WP_088494147.1	hypothetical protein	-
GTK47_RS02215	447133..447594	+	462	WP_165121988.1	DUF1097 domain-containing protein	-
GTK47_RS02220	447695..448378	-	684	WP_165126436.1	ABC transporter ATP-binding protein	-
GTK47_RS02225	448309..449226	-	918	WP_165121989.1	TonB-dependent receptor plug domain-containing protein	-
GTK47_RS02230	449374..449838	-	465	WP_165121990.1	iron chelate uptake ABC transporter family permease subunit	-
GTK47_RS02235	450110..450910	-	801	WP_165121991.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49571.39 Da
• Isoelectric Point: 5.8252

>T147000 WP_165121987.1 NZ_CP047639:444659-445972 [Proteus sp. ZN5]
MASLDVYMNEYYVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLTAVGADTVGALRLLPSGSTPANIKKIEYNKLDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIVKTENIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIISIMNYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGQGLNSRDAKLAMGLQASRGKKYAIEQIFPRHFYQTAEAASFDPSLMTDILRYFYKEM
DDAIKRVKQQLPDDFPSEISNKILNGMKTRSARLANI

Nucleotide

• Length: 1314 bp

>T147000 NZ_CP062840:c2570-1530 [Escherichia coli]
ATGGCACAGAACCCGTTTAAAGCACTAAATATCAATATTGACAAGATTGAGTCTGCTCTGACGCAGAATGGCGTCACAAA
CTATTCCTCTAATGTAAAAAACGAAAGAGAAACTCACATATCTGGCACATATAAAGGAATAGACTTCTTAATAAAACTAA
TGCCATCAGGCGGAAATACCACTATCGGAAGAGCGTCTGGGCAAAATAACACTTACTTTGATGAAATCGCCTTGATTATA
AAAGAAAACTGTTTGTATTCAGACACAAAGAACTTTGAATACACCATTCCAAAATTCAGTGATGATGACAGGGCAAATCT
ATTTGAATTTCTTTCTGAAGAGGGGATAACAATAACAGAAGATAATAATAACGATCCTAATTGTAAACACCAATATATTA
TGACCACCAGCAATGGTGACAGGGTCAGGGCAAAAATTTACAAGCGCGGCTCTATTCAATTCCAAGGAAAATACCTTCAA
ATCGCGAGTTTGATTAACGATTTCATGTGCTCAATACTAAACATGAAAGAGATTGTCGAACAAAAAAATAAAGAATTTAA
TGTTGACATAAAAAAAGAAACTATTGAGTCCGAGTTGCATAGCAAACTACCAAAAAGCATCGATAAAATCCATGAAGATA
TCAAAAAACAGCTATCATGCTCGCTAATAATGAAAAAAATAGATGTCGAAATGGAAGATTACTCAACATACTGCTTCTCT
GCATTAAGAGCTATAGAAGGCTTTATATATCAAATACTTAATGATGTTTGCAATCCATCATCATCAAAGAACCTTGGCGA
ATACTTCACTGAAAACAAACCCAAATATATAATCAGAGAAATACACCAAGAAACTATAAATGGTGAAATAGCGGAAGTTT
TGTGTGAATGCTACACTTACTGGCATGAGAACAGGCATGGTTTGTTTCATATGAAACCAGGAATAGCTGACACGAAGACA
ATTAACAAATTAGAATCAATCGCAATCATCGATACCGTTTGCCAATTAATAGATGGTGGCGTAGCTAGGTTGAAATTATG
A

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9848.40 Da
• Isoelectric Point: 10.0139

>AT147000 WP_072070485.1 NZ_CP047639:444401-444658 [Proteus sp. ZN5]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT147000 NZ_CP062840:c1533-1153 [Escherichia coli]
ATGAAAAAAGATAAAAAATATCAAATAGAAGCAATAAAAAATAAAGATAAAACTTTATTTATTGTCTATGCTACTGATAT
TTATAGCCCGAGCGAATTTTTCTCAAAAATCGAATCCGACTTGAAGAAAAAGAAAAGCAAGGGTGATGTTTTTTTTGATT
TAATAATTCCTAACGGTGGAAAAAAAGATCGTTACGTCTATACGTCATTTAATGGCGAGAAGTTTTCAAGTTACACATTA
AACAAAGTTACGAAAACTGATGAATATAATGATTTATCTGAGCTCTCGGCTTCGTTCTTTAAAAAGAACTTTGATAAGAT
CAACGTAAACCTTCTATCCAAAGCCACATCATTTGCTTTGAAAAAAGGCATTCCAATATAA